1 Ocak 2022 Dergi makalesi Açık Erişim

Ahan, Recep E.; Hanifehnezhad, Alireza; Kehribar, Ebru S.; Oguzoglu, Tuba C.; Foldes, Katalin; Ozcelik, Cemile E.; Filazi, Nazlican; Oztop, Sidika; Palaz, Fahreddin; Onder, Sevgen; Bozkurt, Eray U.; Ergunay, Koray; Ozkul, Aykut; Seker, Urartu Ozgur Safak

Dublin Core

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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Ahan, Recep E.</dc:creator>
  <dc:creator>Hanifehnezhad, Alireza</dc:creator>
  <dc:creator>Kehribar, Ebru S.</dc:creator>
  <dc:creator>Oguzoglu, Tuba C.</dc:creator>
  <dc:creator>Foldes, Katalin</dc:creator>
  <dc:creator>Ozcelik, Cemile E.</dc:creator>
  <dc:creator>Filazi, Nazlican</dc:creator>
  <dc:creator>Oztop, Sidika</dc:creator>
  <dc:creator>Palaz, Fahreddin</dc:creator>
  <dc:creator>Onder, Sevgen</dc:creator>
  <dc:creator>Bozkurt, Eray U.</dc:creator>
  <dc:creator>Ergunay, Koray</dc:creator>
  <dc:creator>Ozkul, Aykut</dc:creator>
  <dc:creator>Seker, Urartu Ozgur Safak</dc:creator>
  <dc:date>2022-01-01</dc:date>
  <dc:description>The COVID-19 (coronavirus disease-19) pandemic affected more than 180 million people around the globe, causing more than five million deaths as of January 2022. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the new coronavirus, has been identified as the primary cause of the infection. The number of vaccinated people is increasing; however, prophylactic drugs are highly demanded to ensure secure social contact. A number of drug molecules have been repurposed to fight against SARS-CoV-2, and some of them have been proven to be effective in preventing hospitalization or ICU admissions. Here, we demonstrated griffithsin (GRFT), a lectin protein, to block the entry of SARS-CoV-2 and its variants, Delta and Omicron, into the Vero E6 cell lines and IFNAR(-/-) mouse models by attaching to the spike protein of SARS-CoV-2. Given the current mutation frequency of SARS-CoV-2, we believe that GRFT protein-based drugs will have a high impact in preventing the transmission of both the Wuhan strain as well as any other emerging variants, including Delta and Omicron variants, causing the high-speed spread of COVID-19.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/253305</dc:identifier>
  <dc:identifier>oai:aperta.ulakbim.gov.tr:253305</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>ACS INFECTIOUS DISEASES 8(7) 1253-1264</dc:source>
  <dc:title>A Highly Potent SARS-CoV-2 Blocking Lectin Protein</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>