1 Ocak 2022 Dergi makalesi Açık Erişim

Ahan, Recep E.; Hanifehnezhad, Alireza; Kehribar, Ebru S.; Oguzoglu, Tuba C.; Foldes, Katalin; Ozcelik, Cemile E.; Filazi, Nazlican; Oztop, Sidika; Palaz, Fahreddin; Onder, Sevgen; Bozkurt, Eray U.; Ergunay, Koray; Ozkul, Aykut; Seker, Urartu Ozgur Safak

DataCite XML

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd">
  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/253305</identifier>
  <creators>
    <creator>
      <creatorName>Ahan, Recep E.</creatorName>
      <givenName>Recep E.</givenName>
      <familyName>Ahan</familyName>
      <affiliation>Bilkent Univ, UNAM Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Hanifehnezhad, Alireza</creatorName>
      <givenName>Alireza</givenName>
      <familyName>Hanifehnezhad</familyName>
      <affiliation>Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kehribar, Ebru S.</creatorName>
      <givenName>Ebru S.</givenName>
      <familyName>Kehribar</familyName>
      <affiliation>Bilkent Univ, UNAM Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Oguzoglu, Tuba C.</creatorName>
      <givenName>Tuba C.</givenName>
      <familyName>Oguzoglu</familyName>
      <affiliation>Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Foldes, Katalin</creatorName>
      <givenName>Katalin</givenName>
      <familyName>Foldes</familyName>
      <affiliation>Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozcelik, Cemile E.</creatorName>
      <givenName>Cemile E.</givenName>
      <familyName>Ozcelik</familyName>
      <affiliation>Bilkent Univ, UNAM Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Filazi, Nazlican</creatorName>
      <givenName>Nazlican</givenName>
      <familyName>Filazi</familyName>
      <affiliation>Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Oztop, Sidika</creatorName>
      <givenName>Sidika</givenName>
      <familyName>Oztop</familyName>
      <affiliation>Baskent Univ, Adana Dr Turgut Noyan Med &amp; Res Ctr, Dept Immunol, TR-01250 Adana, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Palaz, Fahreddin</creatorName>
      <givenName>Fahreddin</givenName>
      <familyName>Palaz</familyName>
      <affiliation>Hacettepe Univ, Fac Med, TR-06230 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Onder, Sevgen</creatorName>
      <givenName>Sevgen</givenName>
      <familyName>Onder</familyName>
      <affiliation>Hacettepe Univ, Fac Med, Dept Med Pathol, TR-06230 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bozkurt, Eray U.</creatorName>
      <givenName>Eray U.</givenName>
      <familyName>Bozkurt</familyName>
      <affiliation>Bilkent Univ, UNAM Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ergunay, Koray</creatorName>
      <givenName>Koray</givenName>
      <familyName>Ergunay</familyName>
      <affiliation>Hacettepe Univ, Fac Med, Dept Med Microbiol, Virol Unit, TR-06230 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozkul, Aykut</creatorName>
      <givenName>Aykut</givenName>
      <familyName>Ozkul</familyName>
    </creator>
    <creator>
      <creatorName>Seker, Urartu Ozgur Safak</creatorName>
      <givenName>Urartu Ozgur Safak</givenName>
      <familyName>Seker</familyName>
      <affiliation>Bilkent Univ, UNAM Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>A Highly Potent Sars-Cov-2 Blocking Lectin Protein</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2022</publicationYear>
  <dates>
    <date dateType="Issued">2022-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/253305</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1021/acsinfecdis.2c00006</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The COVID-19 (coronavirus disease-19) pandemic affected more than 180 million people around the globe, causing more than five million deaths as of January 2022. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the new coronavirus, has been identified as the primary cause of the infection. The number of vaccinated people is increasing; however, prophylactic drugs are highly demanded to ensure secure social contact. A number of drug molecules have been repurposed to fight against SARS-CoV-2, and some of them have been proven to be effective in preventing hospitalization or ICU admissions. Here, we demonstrated griffithsin (GRFT), a lectin protein, to block the entry of SARS-CoV-2 and its variants, Delta and Omicron, into the Vero E6 cell lines and IFNAR(-/-) mouse models by attaching to the spike protein of SARS-CoV-2. Given the current mutation frequency of SARS-CoV-2, we believe that GRFT protein-based drugs will have a high impact in preventing the transmission of both the Wuhan strain as well as any other emerging variants, including Delta and Omicron variants, causing the high-speed spread of COVID-19.</description>
  </descriptions>
</resource>