1 Ocak 2022 Dergi makalesi Açık Erişim

Ahan, Recep E.; Hanifehnezhad, Alireza; Kehribar, Ebru S.; Oguzoglu, Tuba C.; Foldes, Katalin; Ozcelik, Cemile E.; Filazi, Nazlican; Oztop, Sidika; Palaz, Fahreddin; Onder, Sevgen; Bozkurt, Eray U.; Ergunay, Koray; Ozkul, Aykut; Seker, Urartu Ozgur Safak

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{
  "@context": "https://schema.org/", 
  "@id": 253305, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, UNAM Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
      "name": "Ahan, Recep E."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey", 
      "name": "Hanifehnezhad, Alireza"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, UNAM Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
      "name": "Kehribar, Ebru S."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey", 
      "name": "Oguzoglu, Tuba C."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey", 
      "name": "Foldes, Katalin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, UNAM Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
      "name": "Ozcelik, Cemile E."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey", 
      "name": "Filazi, Nazlican"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Baskent Univ, Adana Dr Turgut Noyan Med & Res Ctr, Dept Immunol, TR-01250 Adana, Turkey", 
      "name": "Oztop, Sidika"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Fac Med, TR-06230 Ankara, Turkey", 
      "name": "Palaz, Fahreddin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Fac Med, Dept Med Pathol, TR-06230 Ankara, Turkey", 
      "name": "Onder, Sevgen"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, UNAM Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
      "name": "Bozkurt, Eray U."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Fac Med, Dept Med Microbiol, Virol Unit, TR-06230 Ankara, Turkey", 
      "name": "Ergunay, Koray"
    }, 
    {
      "@type": "Person", 
      "name": "Ozkul, Aykut"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, UNAM Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
      "name": "Seker, Urartu Ozgur Safak"
    }
  ], 
  "datePublished": "2022-01-01", 
  "description": "The COVID-19 (coronavirus disease-19) pandemic affected more than 180 million people around the globe, causing more than five million deaths as of January 2022. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the new coronavirus, has been identified as the primary cause of the infection. The number of vaccinated people is increasing; however, prophylactic drugs are highly demanded to ensure secure social contact. A number of drug molecules have been repurposed to fight against SARS-CoV-2, and some of them have been proven to be effective in preventing hospitalization or ICU admissions. Here, we demonstrated griffithsin (GRFT), a lectin protein, to block the entry of SARS-CoV-2 and its variants, Delta and Omicron, into the Vero E6 cell lines and IFNAR(-/-) mouse models by attaching to the spike protein of SARS-CoV-2. Given the current mutation frequency of SARS-CoV-2, we believe that GRFT protein-based drugs will have a high impact in preventing the transmission of both the Wuhan strain as well as any other emerging variants, including Delta and Omicron variants, causing the high-speed spread of COVID-19.", 
  "headline": "A Highly Potent SARS-CoV-2 Blocking Lectin Protein", 
  "identifier": 253305, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "A Highly Potent SARS-CoV-2 Blocking Lectin Protein", 
  "url": "https://aperta.ulakbim.gov.tr/record/253305"
}