1 Ocak 2022 Dergi makalesi Açık Erişim

Ahan, Recep E.; Hanifehnezhad, Alireza; Kehribar, Ebru S.; Oguzoglu, Tuba C.; Foldes, Katalin; Ozcelik, Cemile E.; Filazi, Nazlican; Oztop, Sidika; Palaz, Fahreddin; Onder, Sevgen; Bozkurt, Eray U.; Ergunay, Koray; Ozkul, Aykut; Seker, Urartu Ozgur Safak

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  "created": "2023-07-28T18:53:06.618349+00:00", 
  "doi": "10.1021/acsinfecdis.2c00006", 
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    "creators": [
      {
        "affiliation": "Bilkent Univ, UNAM Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
        "name": "Ahan, Recep E."
      }, 
      {
        "affiliation": "Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey", 
        "name": "Hanifehnezhad, Alireza"
      }, 
      {
        "affiliation": "Bilkent Univ, UNAM Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
        "name": "Kehribar, Ebru S."
      }, 
      {
        "affiliation": "Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey", 
        "name": "Oguzoglu, Tuba C."
      }, 
      {
        "affiliation": "Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey", 
        "name": "Foldes, Katalin"
      }, 
      {
        "affiliation": "Bilkent Univ, UNAM Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
        "name": "Ozcelik, Cemile E."
      }, 
      {
        "affiliation": "Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey", 
        "name": "Filazi, Nazlican"
      }, 
      {
        "affiliation": "Baskent Univ, Adana Dr Turgut Noyan Med & Res Ctr, Dept Immunol, TR-01250 Adana, Turkey", 
        "name": "Oztop, Sidika"
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Med, TR-06230 Ankara, Turkey", 
        "name": "Palaz, Fahreddin"
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Med, Dept Med Pathol, TR-06230 Ankara, Turkey", 
        "name": "Onder, Sevgen"
      }, 
      {
        "affiliation": "Bilkent Univ, UNAM Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
        "name": "Bozkurt, Eray U."
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Med, Dept Med Microbiol, Virol Unit, TR-06230 Ankara, Turkey", 
        "name": "Ergunay, Koray"
      }, 
      {
        "name": "Ozkul, Aykut"
      }, 
      {
        "affiliation": "Bilkent Univ, UNAM Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
        "name": "Seker, Urartu Ozgur Safak"
      }
    ], 
    "description": "The COVID-19 (coronavirus disease-19) pandemic affected more than 180 million people around the globe, causing more than five million deaths as of January 2022. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the new coronavirus, has been identified as the primary cause of the infection. The number of vaccinated people is increasing; however, prophylactic drugs are highly demanded to ensure secure social contact. A number of drug molecules have been repurposed to fight against SARS-CoV-2, and some of them have been proven to be effective in preventing hospitalization or ICU admissions. Here, we demonstrated griffithsin (GRFT), a lectin protein, to block the entry of SARS-CoV-2 and its variants, Delta and Omicron, into the Vero E6 cell lines and IFNAR(-/-) mouse models by attaching to the spike protein of SARS-CoV-2. Given the current mutation frequency of SARS-CoV-2, we believe that GRFT protein-based drugs will have a high impact in preventing the transmission of both the Wuhan strain as well as any other emerging variants, including Delta and Omicron variants, causing the high-speed spread of COVID-19.", 
    "doi": "10.1021/acsinfecdis.2c00006", 
    "has_grant": false, 
    "journal": {
      "issue": "7", 
      "pages": "1253-1264", 
      "title": "ACS INFECTIOUS DISEASES", 
      "volume": "8"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2022-01-01", 
    "relations": {
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    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "science_branches": [
      "Di\u011fer"
    ], 
    "title": "A Highly Potent SARS-CoV-2 Blocking Lectin Protein"
  }, 
  "owners": [
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  "revision": 1, 
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