1 Ocak 2022 Dergi makalesi Açık Erişim

Ahan, Recep E.; Hanifehnezhad, Alireza; Kehribar, Ebru S.; Oguzoglu, Tuba C.; Foldes, Katalin; Ozcelik, Cemile E.; Filazi, Nazlican; Oztop, Sidika; Palaz, Fahreddin; Onder, Sevgen; Bozkurt, Eray U.; Ergunay, Koray; Ozkul, Aykut; Seker, Urartu Ozgur Safak

Citation Style Language JSON

{
  "DOI": "10.1021/acsinfecdis.2c00006", 
  "abstract": "The COVID-19 (coronavirus disease-19) pandemic affected more than 180 million people around the globe, causing more than five million deaths as of January 2022. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the new coronavirus, has been identified as the primary cause of the infection. The number of vaccinated people is increasing; however, prophylactic drugs are highly demanded to ensure secure social contact. A number of drug molecules have been repurposed to fight against SARS-CoV-2, and some of them have been proven to be effective in preventing hospitalization or ICU admissions. Here, we demonstrated griffithsin (GRFT), a lectin protein, to block the entry of SARS-CoV-2 and its variants, Delta and Omicron, into the Vero E6 cell lines and IFNAR(-/-) mouse models by attaching to the spike protein of SARS-CoV-2. Given the current mutation frequency of SARS-CoV-2, we believe that GRFT protein-based drugs will have a high impact in preventing the transmission of both the Wuhan strain as well as any other emerging variants, including Delta and Omicron variants, causing the high-speed spread of COVID-19.", 
  "author": [
    {
      "family": "Ahan", 
      "given": " Recep E."
    }, 
    {
      "family": "Hanifehnezhad", 
      "given": " Alireza"
    }, 
    {
      "family": "Kehribar", 
      "given": " Ebru S."
    }, 
    {
      "family": "Oguzoglu", 
      "given": " Tuba C."
    }, 
    {
      "family": "Foldes", 
      "given": " Katalin"
    }, 
    {
      "family": "Ozcelik", 
      "given": " Cemile E."
    }, 
    {
      "family": "Filazi", 
      "given": " Nazlican"
    }, 
    {
      "family": "Oztop", 
      "given": " Sidika"
    }, 
    {
      "family": "Palaz", 
      "given": " Fahreddin"
    }, 
    {
      "family": "Onder", 
      "given": " Sevgen"
    }, 
    {
      "family": "Bozkurt", 
      "given": " Eray U."
    }, 
    {
      "family": "Ergunay", 
      "given": " Koray"
    }, 
    {
      "family": "Ozkul", 
      "given": " Aykut"
    }, 
    {
      "family": "Seker", 
      "given": " Urartu Ozgur Safak"
    }
  ], 
  "container_title": "ACS INFECTIOUS DISEASES", 
  "id": "253305", 
  "issue": "7", 
  "issued": {
    "date-parts": [
      [
        2022, 
        1, 
        1
      ]
    ]
  }, 
  "page": "1253-1264", 
  "title": "A Highly Potent SARS-CoV-2 Blocking Lectin Protein", 
  "type": "article-journal", 
  "volume": "8"
}