1 Ocak 2021 Dergi makalesi Açık Erişim

Koyas, Altay; Tucer, Suat; Kayhan, Merve; Savas, Ali Can; Akdemir, Imran; Cekic, Caglar

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    <subfield code="a">The nucleoside adenosine accumulates extracellularly in solid tumors and inhibits CD8(+) T cells by activating adenosine receptors. The cytokine interleukin-7 (IL-7), which is produced by various tissues and tumors, promotes the survival and maintenance of T cells. Adenosine and IL-7 signaling are being clinically targeted separately or in combination with other therapies for solid tumor indications. Here, we found that IL-7 signaling promoted the accumulation of tumor-associated CD8(+) T cells, in part, by preventing adenosine-mediated immunosuppression. Inhibition of the transcription factor FoxO1 downstream of IL-7 receptor signaling was important for protecting CD8(+) T cells from suppression by adenosine. These findings have implications for the development of new approaches for cancer immunotherapies that target the adenosine pathway.</subfield>
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    <subfield code="a">Koyas, Altay</subfield>
    <subfield code="u">Bilkent Univ, Dept Mol Biol &amp; Genet, TR-06800 Ankara, Turkey</subfield>
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    <subfield code="a">10.1126/scisignal.abb1269</subfield>
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    <subfield code="a">Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression</subfield>
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    <subfield code="a">Kayhan, Merve</subfield>
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    <subfield code="a">Savas, Ali Can</subfield>
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