1 Ocak 2021 Dergi makalesi Açık Erişim

Koyas, Altay; Tucer, Suat; Kayhan, Merve; Savas, Ali Can; Akdemir, Imran; Cekic, Caglar

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/239106</identifier>
  <creators>
    <creator>
      <creatorName>Koyas, Altay</creatorName>
      <givenName>Altay</givenName>
      <familyName>Koyas</familyName>
      <affiliation>Bilkent Univ, Dept Mol Biol &amp; Genet, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tucer, Suat</creatorName>
      <givenName>Suat</givenName>
      <familyName>Tucer</familyName>
      <affiliation>Bilkent Univ, Dept Mol Biol &amp; Genet, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kayhan, Merve</creatorName>
      <givenName>Merve</givenName>
      <familyName>Kayhan</familyName>
      <affiliation>Bilkent Univ, Dept Mol Biol &amp; Genet, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Savas, Ali Can</creatorName>
      <givenName>Ali Can</givenName>
      <familyName>Savas</familyName>
      <affiliation>Bilkent Univ, Dept Mol Biol &amp; Genet, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akdemir, Imran</creatorName>
      <givenName>Imran</givenName>
      <familyName>Akdemir</familyName>
      <affiliation>Bilkent Univ, Dept Mol Biol &amp; Genet, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cekic, Caglar</creatorName>
      <givenName>Caglar</givenName>
      <familyName>Cekic</familyName>
    </creator>
  </creators>
  <titles>
    <title>Interleukin-7 Protects Cd8(+) T Cells From Adenosine-Mediated Immunosuppression</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/239106</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1126/scisignal.abb1269</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The nucleoside adenosine accumulates extracellularly in solid tumors and inhibits CD8(+) T cells by activating adenosine receptors. The cytokine interleukin-7 (IL-7), which is produced by various tissues and tumors, promotes the survival and maintenance of T cells. Adenosine and IL-7 signaling are being clinically targeted separately or in combination with other therapies for solid tumor indications. Here, we found that IL-7 signaling promoted the accumulation of tumor-associated CD8(+) T cells, in part, by preventing adenosine-mediated immunosuppression. Inhibition of the transcription factor FoxO1 downstream of IL-7 receptor signaling was important for protecting CD8(+) T cells from suppression by adenosine. These findings have implications for the development of new approaches for cancer immunotherapies that target the adenosine pathway.</description>
  </descriptions>
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