1 Ocak 2021 Dergi makalesi Açık Erişim

Koyas, Altay; Tucer, Suat; Kayhan, Merve; Savas, Ali Can; Akdemir, Imran; Cekic, Caglar

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    "creators": [
      {
        "affiliation": "Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey", 
        "name": "Koyas, Altay"
      }, 
      {
        "affiliation": "Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey", 
        "name": "Tucer, Suat"
      }, 
      {
        "affiliation": "Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey", 
        "name": "Kayhan, Merve"
      }, 
      {
        "affiliation": "Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey", 
        "name": "Savas, Ali Can"
      }, 
      {
        "affiliation": "Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey", 
        "name": "Akdemir, Imran"
      }, 
      {
        "name": "Cekic, Caglar"
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    ], 
    "description": "The nucleoside adenosine accumulates extracellularly in solid tumors and inhibits CD8(+) T cells by activating adenosine receptors. The cytokine interleukin-7 (IL-7), which is produced by various tissues and tumors, promotes the survival and maintenance of T cells. Adenosine and IL-7 signaling are being clinically targeted separately or in combination with other therapies for solid tumor indications. Here, we found that IL-7 signaling promoted the accumulation of tumor-associated CD8(+) T cells, in part, by preventing adenosine-mediated immunosuppression. Inhibition of the transcription factor FoxO1 downstream of IL-7 receptor signaling was important for protecting CD8(+) T cells from suppression by adenosine. These findings have implications for the development of new approaches for cancer immunotherapies that target the adenosine pathway.", 
    "doi": "10.1126/scisignal.abb1269", 
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    "journal": {
      "issue": "674", 
      "title": "SCIENCE SIGNALING", 
      "volume": "14"
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      "id": "cc-by"
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    "publication_date": "2021-01-01", 
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      "title": "Dergi makalesi", 
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    "science_branches": [
      "Di\u011fer"
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    "title": "Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression"
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