1 Ocak 2021 Dergi makalesi Açık Erişim

Koyas, Altay; Tucer, Suat; Kayhan, Merve; Savas, Ali Can; Akdemir, Imran; Cekic, Caglar

Citation Style Language JSON

{
  "DOI": "10.1126/scisignal.abb1269", 
  "abstract": "The nucleoside adenosine accumulates extracellularly in solid tumors and inhibits CD8(+) T cells by activating adenosine receptors. The cytokine interleukin-7 (IL-7), which is produced by various tissues and tumors, promotes the survival and maintenance of T cells. Adenosine and IL-7 signaling are being clinically targeted separately or in combination with other therapies for solid tumor indications. Here, we found that IL-7 signaling promoted the accumulation of tumor-associated CD8(+) T cells, in part, by preventing adenosine-mediated immunosuppression. Inhibition of the transcription factor FoxO1 downstream of IL-7 receptor signaling was important for protecting CD8(+) T cells from suppression by adenosine. These findings have implications for the development of new approaches for cancer immunotherapies that target the adenosine pathway.", 
  "author": [
    {
      "family": "Koyas", 
      "given": " Altay"
    }, 
    {
      "family": "Tucer", 
      "given": " Suat"
    }, 
    {
      "family": "Kayhan", 
      "given": " Merve"
    }, 
    {
      "family": "Savas", 
      "given": " Ali Can"
    }, 
    {
      "family": "Akdemir", 
      "given": " Imran"
    }, 
    {
      "family": "Cekic", 
      "given": " Caglar"
    }
  ], 
  "container_title": "SCIENCE SIGNALING", 
  "id": "239106", 
  "issue": "674", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "title": "Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression", 
  "type": "article-journal", 
  "volume": "14"
}