1 Ocak 2021 Dergi makalesi Açık Erişim

Koyas, Altay; Tucer, Suat; Kayhan, Merve; Savas, Ali Can; Akdemir, Imran; Cekic, Caglar

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{
  "@context": "https://schema.org/", 
  "@id": 239106, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey", 
      "name": "Koyas, Altay"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey", 
      "name": "Tucer, Suat"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey", 
      "name": "Kayhan, Merve"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey", 
      "name": "Savas, Ali Can"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey", 
      "name": "Akdemir, Imran"
    }, 
    {
      "@type": "Person", 
      "name": "Cekic, Caglar"
    }
  ], 
  "datePublished": "2021-01-01", 
  "description": "The nucleoside adenosine accumulates extracellularly in solid tumors and inhibits CD8(+) T cells by activating adenosine receptors. The cytokine interleukin-7 (IL-7), which is produced by various tissues and tumors, promotes the survival and maintenance of T cells. Adenosine and IL-7 signaling are being clinically targeted separately or in combination with other therapies for solid tumor indications. Here, we found that IL-7 signaling promoted the accumulation of tumor-associated CD8(+) T cells, in part, by preventing adenosine-mediated immunosuppression. Inhibition of the transcription factor FoxO1 downstream of IL-7 receptor signaling was important for protecting CD8(+) T cells from suppression by adenosine. These findings have implications for the development of new approaches for cancer immunotherapies that target the adenosine pathway.", 
  "headline": "Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression", 
  "identifier": 239106, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression", 
  "url": "https://aperta.ulakbim.gov.tr/record/239106"
}