1 Ocak 2021 Dergi makalesi Açık Erişim

Yurdabak Karaca, Gozde; Kuralay, Filiz; Bingol Ozakpinar, Ozlem; Uygun, Emre; Koc, Umran; Ulusoy, Seyhan; Bosgelmez Tinaz, Gulgun; Oksuz, Lutfi; Uygun Oksuz, Aysegul

Dublin Core

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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Yurdabak Karaca, Gozde</dc:creator>
  <dc:creator>Kuralay, Filiz</dc:creator>
  <dc:creator>Bingol Ozakpinar, Ozlem</dc:creator>
  <dc:creator>Uygun, Emre</dc:creator>
  <dc:creator>Koc, Umran</dc:creator>
  <dc:creator>Ulusoy, Seyhan</dc:creator>
  <dc:creator>Bosgelmez Tinaz, Gulgun</dc:creator>
  <dc:creator>Oksuz, Lutfi</dc:creator>
  <dc:creator>Uygun Oksuz, Aysegul</dc:creator>
  <dc:date>2021-01-01</dc:date>
  <dc:description>The synthesis and biomedical applications of nano/micromotors have attracted great attention. In this work, preparation and characterization of catalytic gold/poly(3,4-ethylenedioxythiophene)/platinum (Au/PEDOT/Pt) micromotors were reported to present their contribution for cancer biomarker miRNA-21 detection. Potential use of these motors for possible cancer treatment was also illustrated after their biocompability had shown. At first, anti-miRNA probe immobilized Au/PEDOT/Pt micromotors (probe DNA/Au/PEDOT/Pt/MMs) were used for the sensitive and selective recognition of synthetic miRNA-21 target sequence to present the proof-of-concept. Then intracellular studies were carried out using four types of cancer cells (human breast cancer cell line, MCF-7, human colorectal adenocarcinoma cell line, HT-29, human lung carcinoma cell line, A-549 and human osteosarcoma cell line, SJSA-1). These studies illustrated the high selectivity of probe DNA/Au/PEDOT/Pt micromotors for MCF-7 and SJSA-1 cells. Later, antiproliferative and cytotoxic effects of the micromotors and their potential use for breast cancer treatment were investigated.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/235258</dc:identifier>
  <dc:identifier>oai:aperta.ulakbim.gov.tr:235258</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>APPLIED NANOSCIENCE</dc:source>
  <dc:title>Catalytic Au/PEDOT/Pt micromotors for cancer biomarker detection and potential breast cancer treatment</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>