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Yurdabak Karaca, Gozde; Kuralay, Filiz; Bingol Ozakpinar, Ozlem; Uygun, Emre; Koc, Umran; Ulusoy, Seyhan; Bosgelmez Tinaz, Gulgun; Oksuz, Lutfi; Uygun Oksuz, Aysegul
{ "DOI": "10.1007/s13204-021-01735-5", "abstract": "The synthesis and biomedical applications of nano/micromotors have attracted great attention. In this work, preparation and characterization of catalytic gold/poly(3,4-ethylenedioxythiophene)/platinum (Au/PEDOT/Pt) micromotors were reported to present their contribution for cancer biomarker miRNA-21 detection. Potential use of these motors for possible cancer treatment was also illustrated after their biocompability had shown. At first, anti-miRNA probe immobilized Au/PEDOT/Pt micromotors (probe DNA/Au/PEDOT/Pt/MMs) were used for the sensitive and selective recognition of synthetic miRNA-21 target sequence to present the proof-of-concept. Then intracellular studies were carried out using four types of cancer cells (human breast cancer cell line, MCF-7, human colorectal adenocarcinoma cell line, HT-29, human lung carcinoma cell line, A-549 and human osteosarcoma cell line, SJSA-1). These studies illustrated the high selectivity of probe DNA/Au/PEDOT/Pt micromotors for MCF-7 and SJSA-1 cells. Later, antiproliferative and cytotoxic effects of the micromotors and their potential use for breast cancer treatment were investigated.", "author": [ { "family": "Yurdabak Karaca", "given": " Gozde" }, { "family": "Kuralay", "given": " Filiz" }, { "family": "Bingol Ozakpinar", "given": " Ozlem" }, { "family": "Uygun", "given": " Emre" }, { "family": "Koc", "given": " Umran" }, { "family": "Ulusoy", "given": " Seyhan" }, { "family": "Bosgelmez Tinaz", "given": " Gulgun" }, { "family": "Oksuz", "given": " Lutfi" }, { "family": "Uygun Oksuz", "given": " Aysegul" } ], "container_title": "APPLIED NANOSCIENCE", "id": "235258", "issued": { "date-parts": [ [ 2021, 1, 1 ] ] }, "title": "Catalytic Au/PEDOT/Pt micromotors for cancer biomarker detection and potential breast cancer treatment", "type": "article-journal" }
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