1 Ocak 2021 Dergi makalesi Açık Erişim

Yurdabak Karaca, Gozde; Kuralay, Filiz; Bingol Ozakpinar, Ozlem; Uygun, Emre; Koc, Umran; Ulusoy, Seyhan; Bosgelmez Tinaz, Gulgun; Oksuz, Lutfi; Uygun Oksuz, Aysegul

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{
  "DOI": "10.1007/s13204-021-01735-5", 
  "abstract": "The synthesis and biomedical applications of nano/micromotors have attracted great attention. In this work, preparation and characterization of catalytic gold/poly(3,4-ethylenedioxythiophene)/platinum (Au/PEDOT/Pt) micromotors were reported to present their contribution for cancer biomarker miRNA-21 detection. Potential use of these motors for possible cancer treatment was also illustrated after their biocompability had shown. At first, anti-miRNA probe immobilized Au/PEDOT/Pt micromotors (probe DNA/Au/PEDOT/Pt/MMs) were used for the sensitive and selective recognition of synthetic miRNA-21 target sequence to present the proof-of-concept. Then intracellular studies were carried out using four types of cancer cells (human breast cancer cell line, MCF-7, human colorectal adenocarcinoma cell line, HT-29, human lung carcinoma cell line, A-549 and human osteosarcoma cell line, SJSA-1). These studies illustrated the high selectivity of probe DNA/Au/PEDOT/Pt micromotors for MCF-7 and SJSA-1 cells. Later, antiproliferative and cytotoxic effects of the micromotors and their potential use for breast cancer treatment were investigated.", 
  "author": [
    {
      "family": "Yurdabak Karaca", 
      "given": " Gozde"
    }, 
    {
      "family": "Kuralay", 
      "given": " Filiz"
    }, 
    {
      "family": "Bingol Ozakpinar", 
      "given": " Ozlem"
    }, 
    {
      "family": "Uygun", 
      "given": " Emre"
    }, 
    {
      "family": "Koc", 
      "given": " Umran"
    }, 
    {
      "family": "Ulusoy", 
      "given": " Seyhan"
    }, 
    {
      "family": "Bosgelmez Tinaz", 
      "given": " Gulgun"
    }, 
    {
      "family": "Oksuz", 
      "given": " Lutfi"
    }, 
    {
      "family": "Uygun Oksuz", 
      "given": " Aysegul"
    }
  ], 
  "container_title": "APPLIED NANOSCIENCE", 
  "id": "235258", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "title": "Catalytic Au/PEDOT/Pt micromotors for cancer biomarker detection and potential breast cancer treatment", 
  "type": "article-journal"
}