1 Ocak 2021 Dergi makalesi Açık Erişim

Yurdabak Karaca, Gozde; Kuralay, Filiz; Bingol Ozakpinar, Ozlem; Uygun, Emre; Koc, Umran; Ulusoy, Seyhan; Bosgelmez Tinaz, Gulgun; Oksuz, Lutfi; Uygun Oksuz, Aysegul

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    "creators": [
      {
        "name": "Yurdabak Karaca, Gozde"
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      {
        "affiliation": "Hacettepe Univ, Fac Sci, Dept Chem, TR-06800 Ankara, Turkey", 
        "name": "Kuralay, Filiz"
      }, 
      {
        "affiliation": "Marmara Univ, Fac Pharm, Dept Biochem, TR-34668 Istanbul, Turkey", 
        "name": "Bingol Ozakpinar, Ozlem"
      }, 
      {
        "affiliation": "Suleyman Demirel Univ, Fac Engn, Dept Civil Engn, TR-32260 Isparta, Turkey", 
        "name": "Uygun, Emre"
      }, 
      {
        "affiliation": "Suleyman Demirel Univ, Fac Arts & Sci, Dept Phys, TR-32260 Isparta, Turkey", 
        "name": "Koc, Umran"
      }, 
      {
        "affiliation": "Suleyman Demirel Univ, Fac Arts & Sci, Dept Biol, TR-32260 Isparta, Turkey", 
        "name": "Ulusoy, Seyhan"
      }, 
      {
        "affiliation": "Marmara Univ, Fac Pharm, Dept Basic Pharmaceut Sci, TR-34668 Istanbul, Turkey", 
        "name": "Bosgelmez Tinaz, Gulgun"
      }, 
      {
        "affiliation": "Suleyman Demirel Univ, Fac Arts & Sci, Dept Phys, TR-32260 Isparta, Turkey", 
        "name": "Oksuz, Lutfi"
      }, 
      {
        "name": "Uygun Oksuz, Aysegul"
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    ], 
    "description": "The synthesis and biomedical applications of nano/micromotors have attracted great attention. In this work, preparation and characterization of catalytic gold/poly(3,4-ethylenedioxythiophene)/platinum (Au/PEDOT/Pt) micromotors were reported to present their contribution for cancer biomarker miRNA-21 detection. Potential use of these motors for possible cancer treatment was also illustrated after their biocompability had shown. At first, anti-miRNA probe immobilized Au/PEDOT/Pt micromotors (probe DNA/Au/PEDOT/Pt/MMs) were used for the sensitive and selective recognition of synthetic miRNA-21 target sequence to present the proof-of-concept. Then intracellular studies were carried out using four types of cancer cells (human breast cancer cell line, MCF-7, human colorectal adenocarcinoma cell line, HT-29, human lung carcinoma cell line, A-549 and human osteosarcoma cell line, SJSA-1). These studies illustrated the high selectivity of probe DNA/Au/PEDOT/Pt micromotors for MCF-7 and SJSA-1 cells. Later, antiproliferative and cytotoxic effects of the micromotors and their potential use for breast cancer treatment were investigated.", 
    "doi": "10.1007/s13204-021-01735-5", 
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    "journal": {
      "title": "APPLIED NANOSCIENCE"
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    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
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    "science_branches": [
      "Di\u011fer"
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    "title": "Catalytic Au/PEDOT/Pt micromotors for cancer biomarker detection and potential breast cancer treatment"
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