1 Ocak 2021 Dergi makalesi Açık Erişim

Yurdabak Karaca, Gozde; Kuralay, Filiz; Bingol Ozakpinar, Ozlem; Uygun, Emre; Koc, Umran; Ulusoy, Seyhan; Bosgelmez Tinaz, Gulgun; Oksuz, Lutfi; Uygun Oksuz, Aysegul

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/235258</identifier>
  <creators>
    <creator>
      <creatorName>Yurdabak Karaca, Gozde</creatorName>
      <givenName>Gozde</givenName>
      <familyName>Yurdabak Karaca</familyName>
    </creator>
    <creator>
      <creatorName>Kuralay, Filiz</creatorName>
      <givenName>Filiz</givenName>
      <familyName>Kuralay</familyName>
      <affiliation>Hacettepe Univ, Fac Sci, Dept Chem, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bingol Ozakpinar, Ozlem</creatorName>
      <givenName>Ozlem</givenName>
      <familyName>Bingol Ozakpinar</familyName>
      <affiliation>Marmara Univ, Fac Pharm, Dept Biochem, TR-34668 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Uygun, Emre</creatorName>
      <givenName>Emre</givenName>
      <familyName>Uygun</familyName>
      <affiliation>Suleyman Demirel Univ, Fac Engn, Dept Civil Engn, TR-32260 Isparta, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Koc, Umran</creatorName>
      <givenName>Umran</givenName>
      <familyName>Koc</familyName>
      <affiliation>Suleyman Demirel Univ, Fac Arts &amp; Sci, Dept Phys, TR-32260 Isparta, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ulusoy, Seyhan</creatorName>
      <givenName>Seyhan</givenName>
      <familyName>Ulusoy</familyName>
      <affiliation>Suleyman Demirel Univ, Fac Arts &amp; Sci, Dept Biol, TR-32260 Isparta, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bosgelmez Tinaz, Gulgun</creatorName>
      <givenName>Gulgun</givenName>
      <familyName>Bosgelmez Tinaz</familyName>
      <affiliation>Marmara Univ, Fac Pharm, Dept Basic Pharmaceut Sci, TR-34668 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Oksuz, Lutfi</creatorName>
      <givenName>Lutfi</givenName>
      <familyName>Oksuz</familyName>
      <affiliation>Suleyman Demirel Univ, Fac Arts &amp; Sci, Dept Phys, TR-32260 Isparta, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Uygun Oksuz, Aysegul</creatorName>
      <givenName>Aysegul</givenName>
      <familyName>Uygun Oksuz</familyName>
    </creator>
  </creators>
  <titles>
    <title>Catalytic Au/Pedot/Pt Micromotors For Cancer Biomarker Detection And Potential Breast Cancer Treatment</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/235258</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s13204-021-01735-5</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The synthesis and biomedical applications of nano/micromotors have attracted great attention. In this work, preparation and characterization of catalytic gold/poly(3,4-ethylenedioxythiophene)/platinum (Au/PEDOT/Pt) micromotors were reported to present their contribution for cancer biomarker miRNA-21 detection. Potential use of these motors for possible cancer treatment was also illustrated after their biocompability had shown. At first, anti-miRNA probe immobilized Au/PEDOT/Pt micromotors (probe DNA/Au/PEDOT/Pt/MMs) were used for the sensitive and selective recognition of synthetic miRNA-21 target sequence to present the proof-of-concept. Then intracellular studies were carried out using four types of cancer cells (human breast cancer cell line, MCF-7, human colorectal adenocarcinoma cell line, HT-29, human lung carcinoma cell line, A-549 and human osteosarcoma cell line, SJSA-1). These studies illustrated the high selectivity of probe DNA/Au/PEDOT/Pt micromotors for MCF-7 and SJSA-1 cells. Later, antiproliferative and cytotoxic effects of the micromotors and their potential use for breast cancer treatment were investigated.</description>
  </descriptions>
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