Dergi makalesi Açık Erişim
Yurdabak Karaca, Gozde; Kuralay, Filiz; Bingol Ozakpinar, Ozlem; Uygun, Emre; Koc, Umran; Ulusoy, Seyhan; Bosgelmez Tinaz, Gulgun; Oksuz, Lutfi; Uygun Oksuz, Aysegul
<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd"> <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/235258</identifier> <creators> <creator> <creatorName>Yurdabak Karaca, Gozde</creatorName> <givenName>Gozde</givenName> <familyName>Yurdabak Karaca</familyName> </creator> <creator> <creatorName>Kuralay, Filiz</creatorName> <givenName>Filiz</givenName> <familyName>Kuralay</familyName> <affiliation>Hacettepe Univ, Fac Sci, Dept Chem, TR-06800 Ankara, Turkey</affiliation> </creator> <creator> <creatorName>Bingol Ozakpinar, Ozlem</creatorName> <givenName>Ozlem</givenName> <familyName>Bingol Ozakpinar</familyName> <affiliation>Marmara Univ, Fac Pharm, Dept Biochem, TR-34668 Istanbul, Turkey</affiliation> </creator> <creator> <creatorName>Uygun, Emre</creatorName> <givenName>Emre</givenName> <familyName>Uygun</familyName> <affiliation>Suleyman Demirel Univ, Fac Engn, Dept Civil Engn, TR-32260 Isparta, Turkey</affiliation> </creator> <creator> <creatorName>Koc, Umran</creatorName> <givenName>Umran</givenName> <familyName>Koc</familyName> <affiliation>Suleyman Demirel Univ, Fac Arts & Sci, Dept Phys, TR-32260 Isparta, Turkey</affiliation> </creator> <creator> <creatorName>Ulusoy, Seyhan</creatorName> <givenName>Seyhan</givenName> <familyName>Ulusoy</familyName> <affiliation>Suleyman Demirel Univ, Fac Arts & Sci, Dept Biol, TR-32260 Isparta, Turkey</affiliation> </creator> <creator> <creatorName>Bosgelmez Tinaz, Gulgun</creatorName> <givenName>Gulgun</givenName> <familyName>Bosgelmez Tinaz</familyName> <affiliation>Marmara Univ, Fac Pharm, Dept Basic Pharmaceut Sci, TR-34668 Istanbul, Turkey</affiliation> </creator> <creator> <creatorName>Oksuz, Lutfi</creatorName> <givenName>Lutfi</givenName> <familyName>Oksuz</familyName> <affiliation>Suleyman Demirel Univ, Fac Arts & Sci, Dept Phys, TR-32260 Isparta, Turkey</affiliation> </creator> <creator> <creatorName>Uygun Oksuz, Aysegul</creatorName> <givenName>Aysegul</givenName> <familyName>Uygun Oksuz</familyName> </creator> </creators> <titles> <title>Catalytic Au/Pedot/Pt Micromotors For Cancer Biomarker Detection And Potential Breast Cancer Treatment</title> </titles> <publisher>Aperta</publisher> <publicationYear>2021</publicationYear> <dates> <date dateType="Issued">2021-01-01</date> </dates> <resourceType resourceTypeGeneral="Text">Journal article</resourceType> <alternateIdentifiers> <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/235258</alternateIdentifier> </alternateIdentifiers> <relatedIdentifiers> <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s13204-021-01735-5</relatedIdentifier> </relatedIdentifiers> <rightsList> <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights> <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights> </rightsList> <descriptions> <description descriptionType="Abstract">The synthesis and biomedical applications of nano/micromotors have attracted great attention. In this work, preparation and characterization of catalytic gold/poly(3,4-ethylenedioxythiophene)/platinum (Au/PEDOT/Pt) micromotors were reported to present their contribution for cancer biomarker miRNA-21 detection. Potential use of these motors for possible cancer treatment was also illustrated after their biocompability had shown. At first, anti-miRNA probe immobilized Au/PEDOT/Pt micromotors (probe DNA/Au/PEDOT/Pt/MMs) were used for the sensitive and selective recognition of synthetic miRNA-21 target sequence to present the proof-of-concept. Then intracellular studies were carried out using four types of cancer cells (human breast cancer cell line, MCF-7, human colorectal adenocarcinoma cell line, HT-29, human lung carcinoma cell line, A-549 and human osteosarcoma cell line, SJSA-1). These studies illustrated the high selectivity of probe DNA/Au/PEDOT/Pt micromotors for MCF-7 and SJSA-1 cells. Later, antiproliferative and cytotoxic effects of the micromotors and their potential use for breast cancer treatment were investigated.</description> </descriptions> </resource>
Görüntülenme | 15 |
İndirme | 2 |
Veri hacmi | 538 Bytes |
Tekil görüntülenme | 12 |
Tekil indirme | 2 |