1 Ocak 2021 Dergi makalesi Açık Erişim

Yurdabak Karaca, Gozde; Kuralay, Filiz; Bingol Ozakpinar, Ozlem; Uygun, Emre; Koc, Umran; Ulusoy, Seyhan; Bosgelmez Tinaz, Gulgun; Oksuz, Lutfi; Uygun Oksuz, Aysegul

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{
  "@context": "https://schema.org/", 
  "@id": 235258, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Yurdabak Karaca, Gozde"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Fac Sci, Dept Chem, TR-06800 Ankara, Turkey", 
      "name": "Kuralay, Filiz"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Marmara Univ, Fac Pharm, Dept Biochem, TR-34668 Istanbul, Turkey", 
      "name": "Bingol Ozakpinar, Ozlem"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Suleyman Demirel Univ, Fac Engn, Dept Civil Engn, TR-32260 Isparta, Turkey", 
      "name": "Uygun, Emre"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Suleyman Demirel Univ, Fac Arts & Sci, Dept Phys, TR-32260 Isparta, Turkey", 
      "name": "Koc, Umran"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Suleyman Demirel Univ, Fac Arts & Sci, Dept Biol, TR-32260 Isparta, Turkey", 
      "name": "Ulusoy, Seyhan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Marmara Univ, Fac Pharm, Dept Basic Pharmaceut Sci, TR-34668 Istanbul, Turkey", 
      "name": "Bosgelmez Tinaz, Gulgun"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Suleyman Demirel Univ, Fac Arts & Sci, Dept Phys, TR-32260 Isparta, Turkey", 
      "name": "Oksuz, Lutfi"
    }, 
    {
      "@type": "Person", 
      "name": "Uygun Oksuz, Aysegul"
    }
  ], 
  "datePublished": "2021-01-01", 
  "description": "The synthesis and biomedical applications of nano/micromotors have attracted great attention. In this work, preparation and characterization of catalytic gold/poly(3,4-ethylenedioxythiophene)/platinum (Au/PEDOT/Pt) micromotors were reported to present their contribution for cancer biomarker miRNA-21 detection. Potential use of these motors for possible cancer treatment was also illustrated after their biocompability had shown. At first, anti-miRNA probe immobilized Au/PEDOT/Pt micromotors (probe DNA/Au/PEDOT/Pt/MMs) were used for the sensitive and selective recognition of synthetic miRNA-21 target sequence to present the proof-of-concept. Then intracellular studies were carried out using four types of cancer cells (human breast cancer cell line, MCF-7, human colorectal adenocarcinoma cell line, HT-29, human lung carcinoma cell line, A-549 and human osteosarcoma cell line, SJSA-1). These studies illustrated the high selectivity of probe DNA/Au/PEDOT/Pt micromotors for MCF-7 and SJSA-1 cells. Later, antiproliferative and cytotoxic effects of the micromotors and their potential use for breast cancer treatment were investigated.", 
  "headline": "Catalytic Au/PEDOT/Pt micromotors for cancer biomarker detection and potential breast cancer treatment", 
  "identifier": 235258, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Catalytic Au/PEDOT/Pt micromotors for cancer biomarker detection and potential breast cancer treatment", 
  "url": "https://aperta.ulakbim.gov.tr/record/235258"
}