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The ovulatory response to human chorionic gonadotropin administration on day 4 post timed artificial insemination improved fertility in repeat breeder cows

Yilmazbas-Mecitoglu, Gulnaz; Gumen, Ahmet; Karakaya-Bilen, Ebru; Keskin, Abdulkadir; Guner, Baris; Cakircali, Rabia


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    "creators": [
      {
        "affiliation": "Univ Bursa Uludag, Fac Vet Med, Dept Obstet & Gynecol, Gonilde Campus, TR-16059 Bursa, Turkey", 
        "name": "Yilmazbas-Mecitoglu, Gulnaz"
      }, 
      {
        "affiliation": "Univ Bursa Uludag, Fac Vet Med, Dept Obstet & Gynecol, Gonilde Campus, TR-16059 Bursa, Turkey", 
        "name": "Gumen, Ahmet"
      }, 
      {
        "affiliation": "Univ Siirt, Fac Vet Med, Dept Obstet & Gynecol, Siirt, Turkey", 
        "name": "Karakaya-Bilen, Ebru"
      }, 
      {
        "affiliation": "Univ Bursa Uludag, Fac Vet Med, Dept Obstet & Gynecol, Gonilde Campus, TR-16059 Bursa, Turkey", 
        "name": "Keskin, Abdulkadir"
      }, 
      {
        "affiliation": "Univ Balikesir, Fac Vet Med, Dept Obstet & Gynecol, Balikesir, Turkey", 
        "name": "Guner, Baris"
      }, 
      {
        "affiliation": "Univ Bursa Uludag, Fac Vet Med, Dept Obstet & Gynecol, Gonilde Campus, TR-16059 Bursa, Turkey", 
        "name": "Cakircali, Rabia"
      }
    ], 
    "description": "This study focused on determining the success of inducing endogenous progesterone source (by formation of accessory corpus luteum) by human chorionic gonadotropin (hCG) administration on day 4 post timed artificial insemination (TAI) and on evaluating the effect of the day of hCG administration (day 4 or 5 post TAI) on pregnancy rates in repeat breeder cows according to their responses to hCG administrations. Non-pregnant cyclic lactating Holstein dairy cows with more than three services despite no clinical reproductive abnormalities were enrolled in the study. All cows (n = 192) received the Ovsynch protocol (GnRH-7d-PGF(2 alpha)-56h-GnRH-16/18h-TAI) and hCG administration (1500 IU, i.m.) was performed in group hCG4 (n = 64) on day 4 and in group hCG5 (n = 68) on day 5 post TAI. The control group (CON, n = 60) did not receive any hCG treatment. The responses (ovulation rate) to hCG (similar to 64%) were similar on days 4 and 5 post TAI. Pregnancy per AI (P/AI) at 31 days was similar among the groups (48.3% in CON, 48.4% in hCG4, and 42.6% in hCG5). Regardless of the day of the treatment (hCG4 + hCG5), the cows had an ovulatory response to hCG (54.1%), and a greater P/AI (P = 0.007) at 31 days than those without a response (29.8%). The administration of hCG on either day 4 or 5 post TAI did not increase overall pregnancy rates, however, the ovulatory response to the post TAI hCG administration on day 4 improved fertility in repeat breeder cows. Further studies are needed with a larger number of animals to reveal this potentiallly beneficial effect.", 
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      "issue": "1", 
      "pages": "15-20", 
      "title": "ACTA VETERINARIA BRNO", 
      "volume": "90"
    }, 
    "license": {
      "id": "cc-by"
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    "publication_date": "2021-01-01", 
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    "title": "The ovulatory response to human chorionic gonadotropin administration on day 4 post timed artificial insemination improved fertility in repeat breeder cows"
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