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The ovulatory response to human chorionic gonadotropin administration on day 4 post timed artificial insemination improved fertility in repeat breeder cows

Yilmazbas-Mecitoglu, Gulnaz; Gumen, Ahmet; Karakaya-Bilen, Ebru; Keskin, Abdulkadir; Guner, Baris; Cakircali, Rabia


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{
  "DOI": "10.2754/avb202190010015", 
  "abstract": "This study focused on determining the success of inducing endogenous progesterone source (by formation of accessory corpus luteum) by human chorionic gonadotropin (hCG) administration on day 4 post timed artificial insemination (TAI) and on evaluating the effect of the day of hCG administration (day 4 or 5 post TAI) on pregnancy rates in repeat breeder cows according to their responses to hCG administrations. Non-pregnant cyclic lactating Holstein dairy cows with more than three services despite no clinical reproductive abnormalities were enrolled in the study. All cows (n = 192) received the Ovsynch protocol (GnRH-7d-PGF(2 alpha)-56h-GnRH-16/18h-TAI) and hCG administration (1500 IU, i.m.) was performed in group hCG4 (n = 64) on day 4 and in group hCG5 (n = 68) on day 5 post TAI. The control group (CON, n = 60) did not receive any hCG treatment. The responses (ovulation rate) to hCG (similar to 64%) were similar on days 4 and 5 post TAI. Pregnancy per AI (P/AI) at 31 days was similar among the groups (48.3% in CON, 48.4% in hCG4, and 42.6% in hCG5). Regardless of the day of the treatment (hCG4 + hCG5), the cows had an ovulatory response to hCG (54.1%), and a greater P/AI (P = 0.007) at 31 days than those without a response (29.8%). The administration of hCG on either day 4 or 5 post TAI did not increase overall pregnancy rates, however, the ovulatory response to the post TAI hCG administration on day 4 improved fertility in repeat breeder cows. Further studies are needed with a larger number of animals to reveal this potentiallly beneficial effect.", 
  "author": [
    {
      "family": "Yilmazbas-Mecitoglu", 
      "given": " Gulnaz"
    }, 
    {
      "family": "Gumen", 
      "given": " Ahmet"
    }, 
    {
      "family": "Karakaya-Bilen", 
      "given": " Ebru"
    }, 
    {
      "family": "Keskin", 
      "given": " Abdulkadir"
    }, 
    {
      "family": "Guner", 
      "given": " Baris"
    }, 
    {
      "family": "Cakircali", 
      "given": " Rabia"
    }
  ], 
  "container_title": "ACTA VETERINARIA BRNO", 
  "id": "234462", 
  "issue": "1", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "page": "15-20", 
  "title": "The ovulatory response to human chorionic gonadotropin administration on day 4 post timed artificial insemination improved fertility in repeat breeder cows", 
  "type": "article-journal", 
  "volume": "90"
}
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