1 Ocak 2021 Dergi makalesi Açık Erişim

Cetin, Sultan; Elmazoglu, Zubeyir; Karaman, Osman; Gunduz, Hande; Gunbas, Gorkem; Kolemen, Safacan

Dublin Core

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  <dc:creator>Cetin, Sultan</dc:creator>
  <dc:creator>Elmazoglu, Zubeyir</dc:creator>
  <dc:creator>Karaman, Osman</dc:creator>
  <dc:creator>Gunduz, Hande</dc:creator>
  <dc:creator>Gunbas, Gorkem</dc:creator>
  <dc:creator>Kolemen, Safacan</dc:creator>
  <dc:date>2021-01-01</dc:date>
  <dc:description>Iodination of the silicon-fluorescein core revealed a new class of highly cytotoxic, red-shifted and water-soluble photosensitizer (SF-I) which is also fairly emissive to serve as a theranostic agent. Singlet oxygen generation capacity of SF-I was evaluated chemically, and up to 45% singlet oxygen quantum yield was reported in aqueous solutions. SF-I was further tested in triple negative breast (MDA MB-231) and colon (HCT-116) cancer cell lines, which are known to have limited chemotherapy options as well as very poor prognosis. SF-I induced efficient singlet oxygen generation and consequent photocytotoxicity in both cell lines upon light irradiation with a negligible dark toxicity while allowing cell imaging at the same time. SF-I marks the first ever example of a silicon xanthene-based photosensitizer and holds a lot of promise as a small-molecule-based theranostic scaffold.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/230154</dc:identifier>
  <dc:identifier>oai:aperta.ulakbim.gov.tr:230154</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>ACS MEDICINAL CHEMISTRY LETTERS 12(5) 752-757</dc:source>
  <dc:title>Balanced Intersystem Crossing in Iodinated Silicon-Fluoresceins Allows New Class of Red Shifted Theranostic Agents</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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