1 Ocak 2021 Dergi makalesi Açık Erişim

Cetin, Sultan; Elmazoglu, Zubeyir; Karaman, Osman; Gunduz, Hande; Gunbas, Gorkem; Kolemen, Safacan

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  "@id": 230154, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Dept Chem, TR-34450 Istanbul, Turkey", 
      "name": "Cetin, Sultan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey", 
      "name": "Elmazoglu, Zubeyir"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey", 
      "name": "Karaman, Osman"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Dept Chem, TR-34450 Istanbul, Turkey", 
      "name": "Gunduz, Hande"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey", 
      "name": "Gunbas, Gorkem"
    }, 
    {
      "@type": "Person", 
      "name": "Kolemen, Safacan"
    }
  ], 
  "datePublished": "2021-01-01", 
  "description": "Iodination of the silicon-fluorescein core revealed a new class of highly cytotoxic, red-shifted and water-soluble photosensitizer (SF-I) which is also fairly emissive to serve as a theranostic agent. Singlet oxygen generation capacity of SF-I was evaluated chemically, and up to 45% singlet oxygen quantum yield was reported in aqueous solutions. SF-I was further tested in triple negative breast (MDA MB-231) and colon (HCT-116) cancer cell lines, which are known to have limited chemotherapy options as well as very poor prognosis. SF-I induced efficient singlet oxygen generation and consequent photocytotoxicity in both cell lines upon light irradiation with a negligible dark toxicity while allowing cell imaging at the same time. SF-I marks the first ever example of a silicon xanthene-based photosensitizer and holds a lot of promise as a small-molecule-based theranostic scaffold.", 
  "headline": "Balanced Intersystem Crossing in Iodinated Silicon-Fluoresceins Allows New Class of Red Shifted Theranostic Agents", 
  "identifier": 230154, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Balanced Intersystem Crossing in Iodinated Silicon-Fluoresceins Allows New Class of Red Shifted Theranostic Agents", 
  "url": "https://aperta.ulakbim.gov.tr/record/230154"
}