1 Ocak 2021 Dergi makalesi Açık Erişim

Cetin, Sultan; Elmazoglu, Zubeyir; Karaman, Osman; Gunduz, Hande; Gunbas, Gorkem; Kolemen, Safacan

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/230154</identifier>
  <creators>
    <creator>
      <creatorName>Cetin, Sultan</creatorName>
      <givenName>Sultan</givenName>
      <familyName>Cetin</familyName>
      <affiliation>Koc Univ, Dept Chem, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Elmazoglu, Zubeyir</creatorName>
      <givenName>Zubeyir</givenName>
      <familyName>Elmazoglu</familyName>
      <affiliation>Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Karaman, Osman</creatorName>
      <givenName>Osman</givenName>
      <familyName>Karaman</familyName>
      <affiliation>Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gunduz, Hande</creatorName>
      <givenName>Hande</givenName>
      <familyName>Gunduz</familyName>
      <affiliation>Koc Univ, Dept Chem, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gunbas, Gorkem</creatorName>
      <givenName>Gorkem</givenName>
      <familyName>Gunbas</familyName>
      <affiliation>Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kolemen, Safacan</creatorName>
      <givenName>Safacan</givenName>
      <familyName>Kolemen</familyName>
    </creator>
  </creators>
  <titles>
    <title>Balanced Intersystem Crossing In Iodinated Silicon-Fluoresceins Allows New Class Of Red Shifted Theranostic Agents</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/230154</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1021/acsmedchemlett.1c00018</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Iodination of the silicon-fluorescein core revealed a new class of highly cytotoxic, red-shifted and water-soluble photosensitizer (SF-I) which is also fairly emissive to serve as a theranostic agent. Singlet oxygen generation capacity of SF-I was evaluated chemically, and up to 45% singlet oxygen quantum yield was reported in aqueous solutions. SF-I was further tested in triple negative breast (MDA MB-231) and colon (HCT-116) cancer cell lines, which are known to have limited chemotherapy options as well as very poor prognosis. SF-I induced efficient singlet oxygen generation and consequent photocytotoxicity in both cell lines upon light irradiation with a negligible dark toxicity while allowing cell imaging at the same time. SF-I marks the first ever example of a silicon xanthene-based photosensitizer and holds a lot of promise as a small-molecule-based theranostic scaffold.</description>
  </descriptions>
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