1 Ocak 2021 Dergi makalesi Açık Erişim

Cetin, Sultan; Elmazoglu, Zubeyir; Karaman, Osman; Gunduz, Hande; Gunbas, Gorkem; Kolemen, Safacan

Citation Style Language JSON

{
  "DOI": "10.1021/acsmedchemlett.1c00018", 
  "abstract": "Iodination of the silicon-fluorescein core revealed a new class of highly cytotoxic, red-shifted and water-soluble photosensitizer (SF-I) which is also fairly emissive to serve as a theranostic agent. Singlet oxygen generation capacity of SF-I was evaluated chemically, and up to 45% singlet oxygen quantum yield was reported in aqueous solutions. SF-I was further tested in triple negative breast (MDA MB-231) and colon (HCT-116) cancer cell lines, which are known to have limited chemotherapy options as well as very poor prognosis. SF-I induced efficient singlet oxygen generation and consequent photocytotoxicity in both cell lines upon light irradiation with a negligible dark toxicity while allowing cell imaging at the same time. SF-I marks the first ever example of a silicon xanthene-based photosensitizer and holds a lot of promise as a small-molecule-based theranostic scaffold.", 
  "author": [
    {
      "family": "Cetin", 
      "given": " Sultan"
    }, 
    {
      "family": "Elmazoglu", 
      "given": " Zubeyir"
    }, 
    {
      "family": "Karaman", 
      "given": " Osman"
    }, 
    {
      "family": "Gunduz", 
      "given": " Hande"
    }, 
    {
      "family": "Gunbas", 
      "given": " Gorkem"
    }, 
    {
      "family": "Kolemen", 
      "given": " Safacan"
    }
  ], 
  "container_title": "ACS MEDICINAL CHEMISTRY LETTERS", 
  "id": "230154", 
  "issue": "5", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "page": "752-757", 
  "title": "Balanced Intersystem Crossing in Iodinated Silicon-Fluoresceins Allows New Class of Red Shifted Theranostic Agents", 
  "type": "article-journal", 
  "volume": "12"
}