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ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart

Jost, N.; Nagy, N.; Corici, C.; Kohajda, Z.; Horvath, A.; Acsai, K.; Biliczki, P.; Levijoki, J.; Pollesello, P.; Koskelainen, T.; Otsomaa, L.; Toth, A.; Papp, J. Gy; Varro, A.; Virag, L.


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{
  "@context": "https://schema.org/", 
  "@id": 14243, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Jost, N."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Szeged, Dept Pharmacol & Pharmacotherapy, Fac Med, H-6720 Szeged, Hungary", 
      "name": "Nagy, N."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Szeged, Dept Pharmacol & Pharmacotherapy, Fac Med, H-6720 Szeged, Hungary", 
      "name": "Corici, C."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hungarian Acad Sci, Div Cardiovasc Pharmacol, Szeged, Hungary", 
      "name": "Kohajda, Z."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hungarian Acad Sci, Div Cardiovasc Pharmacol, Szeged, Hungary", 
      "name": "Horvath, A."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hungarian Acad Sci, Div Cardiovasc Pharmacol, Szeged, Hungary", 
      "name": "Acsai, K."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Szeged, Dept Pharmacol & Pharmacotherapy, Fac Med, H-6720 Szeged, Hungary", 
      "name": "Biliczki, P."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Orion Pharma, Espoo, Finland", 
      "name": "Levijoki, J."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Orion Pharma, Espoo, Finland", 
      "name": "Pollesello, P."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Orion Pharma, Espoo, Finland", 
      "name": "Koskelainen, T."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Orion Pharma, Espoo, Finland", 
      "name": "Otsomaa, L."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Szeged, Dept Pharmacol & Pharmacotherapy, Fac Med, H-6720 Szeged, Hungary", 
      "name": "Toth, A."
    }, 
    {
      "@type": "Person", 
      "name": "Papp, J. Gy"
    }, 
    {
      "@type": "Person", 
      "name": "Varro, A."
    }, 
    {
      "@type": "Person", 
      "name": "Virag, L."
    }
  ], 
  "datePublished": "2013-01-01", 
  "description": "Background and PurposeAt present there are no small molecule inhibitors that show strong selectivity for the Na+/Ca2+ exchanger (NCX). Hence, we studied the electrophysiological effects of acute administration of ORM-10103, a new NCX inhibitor, on the NCX and L-type Ca2+ currents and on the formation of early and delayed afterdepolarizations.", 
  "headline": "ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart", 
  "identifier": 14243, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart", 
  "url": "https://aperta.ulakbim.gov.tr/record/14243"
}
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