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ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart

Jost, N.; Nagy, N.; Corici, C.; Kohajda, Z.; Horvath, A.; Acsai, K.; Biliczki, P.; Levijoki, J.; Pollesello, P.; Koskelainen, T.; Otsomaa, L.; Toth, A.; Papp, J. Gy; Varro, A.; Virag, L.


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      {
        "name": "Jost, N."
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      {
        "affiliation": "Univ Szeged, Dept Pharmacol & Pharmacotherapy, Fac Med, H-6720 Szeged, Hungary", 
        "name": "Nagy, N."
      }, 
      {
        "affiliation": "Univ Szeged, Dept Pharmacol & Pharmacotherapy, Fac Med, H-6720 Szeged, Hungary", 
        "name": "Corici, C."
      }, 
      {
        "affiliation": "Hungarian Acad Sci, Div Cardiovasc Pharmacol, Szeged, Hungary", 
        "name": "Kohajda, Z."
      }, 
      {
        "affiliation": "Hungarian Acad Sci, Div Cardiovasc Pharmacol, Szeged, Hungary", 
        "name": "Horvath, A."
      }, 
      {
        "affiliation": "Hungarian Acad Sci, Div Cardiovasc Pharmacol, Szeged, Hungary", 
        "name": "Acsai, K."
      }, 
      {
        "affiliation": "Univ Szeged, Dept Pharmacol & Pharmacotherapy, Fac Med, H-6720 Szeged, Hungary", 
        "name": "Biliczki, P."
      }, 
      {
        "affiliation": "Orion Pharma, Espoo, Finland", 
        "name": "Levijoki, J."
      }, 
      {
        "affiliation": "Orion Pharma, Espoo, Finland", 
        "name": "Pollesello, P."
      }, 
      {
        "affiliation": "Orion Pharma, Espoo, Finland", 
        "name": "Koskelainen, T."
      }, 
      {
        "affiliation": "Orion Pharma, Espoo, Finland", 
        "name": "Otsomaa, L."
      }, 
      {
        "affiliation": "Univ Szeged, Dept Pharmacol & Pharmacotherapy, Fac Med, H-6720 Szeged, Hungary", 
        "name": "Toth, A."
      }, 
      {
        "name": "Papp, J. Gy"
      }, 
      {
        "name": "Varro, A."
      }, 
      {
        "name": "Virag, L."
      }
    ], 
    "description": "Background and PurposeAt present there are no small molecule inhibitors that show strong selectivity for the Na+/Ca2+ exchanger (NCX). Hence, we studied the electrophysiological effects of acute administration of ORM-10103, a new NCX inhibitor, on the NCX and L-type Ca2+ currents and on the formation of early and delayed afterdepolarizations.", 
    "doi": "10.1111/bph.12228", 
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    "journal": {
      "issue": "4", 
      "pages": "768-778", 
      "title": "BRITISH JOURNAL OF PHARMACOLOGY", 
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    "title": "ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart"
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