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ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart

Jost, N.; Nagy, N.; Corici, C.; Kohajda, Z.; Horvath, A.; Acsai, K.; Biliczki, P.; Levijoki, J.; Pollesello, P.; Koskelainen, T.; Otsomaa, L.; Toth, A.; Papp, J. Gy; Varro, A.; Virag, L.


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/14243</identifier>
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      <creatorName>Jost, N.</creatorName>
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    <creator>
      <creatorName>Nagy, N.</creatorName>
      <givenName>N.</givenName>
      <familyName>Nagy</familyName>
      <affiliation>Univ Szeged, Dept Pharmacol &amp; Pharmacotherapy, Fac Med, H-6720 Szeged, Hungary</affiliation>
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    <creator>
      <creatorName>Corici, C.</creatorName>
      <givenName>C.</givenName>
      <familyName>Corici</familyName>
      <affiliation>Univ Szeged, Dept Pharmacol &amp; Pharmacotherapy, Fac Med, H-6720 Szeged, Hungary</affiliation>
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    <creator>
      <creatorName>Kohajda, Z.</creatorName>
      <givenName>Z.</givenName>
      <familyName>Kohajda</familyName>
      <affiliation>Hungarian Acad Sci, Div Cardiovasc Pharmacol, Szeged, Hungary</affiliation>
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      <creatorName>Horvath, A.</creatorName>
      <givenName>A.</givenName>
      <familyName>Horvath</familyName>
      <affiliation>Hungarian Acad Sci, Div Cardiovasc Pharmacol, Szeged, Hungary</affiliation>
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    <creator>
      <creatorName>Acsai, K.</creatorName>
      <givenName>K.</givenName>
      <familyName>Acsai</familyName>
      <affiliation>Hungarian Acad Sci, Div Cardiovasc Pharmacol, Szeged, Hungary</affiliation>
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    <creator>
      <creatorName>Biliczki, P.</creatorName>
      <givenName>P.</givenName>
      <familyName>Biliczki</familyName>
      <affiliation>Univ Szeged, Dept Pharmacol &amp; Pharmacotherapy, Fac Med, H-6720 Szeged, Hungary</affiliation>
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    <creator>
      <creatorName>Levijoki, J.</creatorName>
      <givenName>J.</givenName>
      <familyName>Levijoki</familyName>
      <affiliation>Orion Pharma, Espoo, Finland</affiliation>
    </creator>
    <creator>
      <creatorName>Pollesello, P.</creatorName>
      <givenName>P.</givenName>
      <familyName>Pollesello</familyName>
      <affiliation>Orion Pharma, Espoo, Finland</affiliation>
    </creator>
    <creator>
      <creatorName>Koskelainen, T.</creatorName>
      <givenName>T.</givenName>
      <familyName>Koskelainen</familyName>
      <affiliation>Orion Pharma, Espoo, Finland</affiliation>
    </creator>
    <creator>
      <creatorName>Otsomaa, L.</creatorName>
      <givenName>L.</givenName>
      <familyName>Otsomaa</familyName>
      <affiliation>Orion Pharma, Espoo, Finland</affiliation>
    </creator>
    <creator>
      <creatorName>Toth, A.</creatorName>
      <givenName>A.</givenName>
      <familyName>Toth</familyName>
      <affiliation>Univ Szeged, Dept Pharmacol &amp; Pharmacotherapy, Fac Med, H-6720 Szeged, Hungary</affiliation>
    </creator>
    <creator>
      <creatorName>Papp, J. Gy</creatorName>
      <givenName>J. Gy</givenName>
      <familyName>Papp</familyName>
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    <creator>
      <creatorName>Varro, A.</creatorName>
      <givenName>A.</givenName>
      <familyName>Varro</familyName>
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      <creatorName>Virag, L.</creatorName>
      <givenName>L.</givenName>
      <familyName>Virag</familyName>
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  <titles>
    <title>Orm-10103, A Novel Specific Inhibitor Of The Na+/Ca2+ Exchanger, Decreases Early And Delayed Afterdepolarizations In The Canine Heart</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2013</publicationYear>
  <dates>
    <date dateType="Issued">2013-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/14243</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1111/bph.12228</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Background and PurposeAt present there are no small molecule inhibitors that show strong selectivity for the Na+/Ca2+ exchanger (NCX). Hence, we studied the electrophysiological effects of acute administration of ORM-10103, a new NCX inhibitor, on the NCX and L-type Ca2+ currents and on the formation of early and delayed afterdepolarizations.</description>
  </descriptions>
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