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ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart

Jost, N.; Nagy, N.; Corici, C.; Kohajda, Z.; Horvath, A.; Acsai, K.; Biliczki, P.; Levijoki, J.; Pollesello, P.; Koskelainen, T.; Otsomaa, L.; Toth, A.; Papp, J. Gy; Varro, A.; Virag, L.


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{
  "DOI": "10.1111/bph.12228", 
  "abstract": "Background and PurposeAt present there are no small molecule inhibitors that show strong selectivity for the Na+/Ca2+ exchanger (NCX). Hence, we studied the electrophysiological effects of acute administration of ORM-10103, a new NCX inhibitor, on the NCX and L-type Ca2+ currents and on the formation of early and delayed afterdepolarizations.", 
  "author": [
    {
      "family": "Jost", 
      "given": " N."
    }, 
    {
      "family": "Nagy", 
      "given": " N."
    }, 
    {
      "family": "Corici", 
      "given": " C."
    }, 
    {
      "family": "Kohajda", 
      "given": " Z."
    }, 
    {
      "family": "Horvath", 
      "given": " A."
    }, 
    {
      "family": "Acsai", 
      "given": " K."
    }, 
    {
      "family": "Biliczki", 
      "given": " P."
    }, 
    {
      "family": "Levijoki", 
      "given": " J."
    }, 
    {
      "family": "Pollesello", 
      "given": " P."
    }, 
    {
      "family": "Koskelainen", 
      "given": " T."
    }, 
    {
      "family": "Otsomaa", 
      "given": " L."
    }, 
    {
      "family": "Toth", 
      "given": " A."
    }, 
    {
      "family": "Papp", 
      "given": " J. Gy"
    }, 
    {
      "family": "Varro", 
      "given": " A."
    }, 
    {
      "family": "Virag", 
      "given": " L."
    }
  ], 
  "container_title": "BRITISH JOURNAL OF PHARMACOLOGY", 
  "id": "14243", 
  "issue": "4", 
  "issued": {
    "date-parts": [
      [
        2013, 
        1, 
        1
      ]
    ]
  }, 
  "page": "768-778", 
  "title": "ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart", 
  "type": "article-journal", 
  "volume": "170"
}
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