1 Ocak 2017 Dergi makalesi Açık Erişim

Kuete, V.; Mafodong, F. L. Dongmo; Celik, I.; Fobofou, S. A. T.; Ndontsa, B. L.; Karaosmanoglu, O.; Weissjohann, L. A.; Tane, P.; Koparal, A. T.; Sivas, H.

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  "@id": 111174, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Kuete, V."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Dschang, Dept Organ Chem, Fac Sci, Dschang, Cameroon", 
      "name": "Mafodong, F. L. Dongmo"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Anadolu Univ, Dept Chem, Fac Sci, Eskisehir, Turkey", 
      "name": "Celik, I."
    }, 
    {
      "@type": "Person", 
      "name": "Fobofou, S. A. T."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Dschang, Dept Organ Chem, Fac Sci, Dschang, Cameroon", 
      "name": "Ndontsa, B. L."
    }, 
    {
      "@type": "Person", 
      "name": "Karaosmanoglu, O."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Liebniz Inst Plant Biochem, Dept Biorgan Chem, Weinberg 3, D-06120 Halle, Saale, Germany", 
      "name": "Weissjohann, L. A."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Dschang, Dept Organ Chem, Fac Sci, Dschang, Cameroon", 
      "name": "Tane, P."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Anadolu Univ, Dept Biol, Sci Fac, Eskisehir, Turkey", 
      "name": "Koparal, A. T."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Anadolu Univ, Dept Biol, Sci Fac, Eskisehir, Turkey", 
      "name": "Sivas, H."
    }
  ], 
  "datePublished": "2017-01-01", 
  "description": "Malignancies constitute a global health concern and chemotherapy remains the main mode of treatment. The present study was designed to evaluate the cytotoxicity of 8 compounds from Desbordesia glaucescens namely lanosta-7,24-dien-3-one (1), friedelanone (2), friedelanol (3), 3,3'-di-O-methylellagic acid (4), 3,3',4'-tri-0-methylellagic acid (5), ellagic acid (6), 3',4'-di-0-methylellagic acid 4-0-beta-o-glucopyranoside (7) and 3,3'-di-0-methylellagic acid 4'-0-beta-c-xylopyranoside (8) against 4 human carcinoma cell lines and normal CRL2120 fibroblasts. The neutral red uptake (NRU) assay was used for cytotoxicity testing. Caspase-Glo assay, cell cycle analysis, measurements of mitochondrial membrane potential (MMP) and levels of reactive oxygen species (ROS) were used to evaluate apoptosis induction. Compounds 4 and 6 as well as doxorubicin had IC50 values below 45 pM in the four tested cancer cell lines meanwhile other compounds displayed selective activity. The IC50 values ranged from 11.23 mu M (towards breast adenocarcinoma MCF-7 cells) to 44.65 mu M (colon carcinoma Caco-2 cells) for 4, from 14.07 mu M (towards MCF-7 cells) to 77.73 mu M (Caco-2 cells) for 6 and from 0.07 mu M (towards SPC212 cells) to 1.01 mu M (A549 cells) for doxorubicin. Compound 4 induced apoptosis in MCF-7 cells mediated by MMP loss. The constituents of Desbordesia glaucescens and especially ellagic acid (6) and its derivative 4 are potential cytotoxic compounds that deserve more investigations towards developing novel antiproliferative drugs against human carcinoma. (C) 2017 SAAB. Published by Elsevier B.V. All rights reserved.", 
  "headline": "In vitro cytotoxicity of compounds isolated from Desbordesia glaucescens against human carcinoma cell lines", 
  "identifier": 111174, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "In vitro cytotoxicity of compounds isolated from Desbordesia glaucescens against human carcinoma cell lines", 
  "url": "https://aperta.ulakbim.gov.tr/record/111174"
}