1 Ocak 2017 Dergi makalesi Açık Erişim

Kuete, V.; Mafodong, F. L. Dongmo; Celik, I.; Fobofou, S. A. T.; Ndontsa, B. L.; Karaosmanoglu, O.; Weissjohann, L. A.; Tane, P.; Koparal, A. T.; Sivas, H.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/111174</identifier>
  <creators>
    <creator>
      <creatorName>Kuete, V.</creatorName>
      <givenName>V.</givenName>
      <familyName>Kuete</familyName>
    </creator>
    <creator>
      <creatorName>Mafodong, F. L. Dongmo</creatorName>
      <givenName>F. L. Dongmo</givenName>
      <familyName>Mafodong</familyName>
      <affiliation>Univ Dschang, Dept Organ Chem, Fac Sci, Dschang, Cameroon</affiliation>
    </creator>
    <creator>
      <creatorName>Celik, I.</creatorName>
      <givenName>I.</givenName>
      <familyName>Celik</familyName>
      <affiliation>Anadolu Univ, Dept Chem, Fac Sci, Eskisehir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Fobofou, S. A. T.</creatorName>
      <givenName>S. A. T.</givenName>
      <familyName>Fobofou</familyName>
    </creator>
    <creator>
      <creatorName>Ndontsa, B. L.</creatorName>
      <givenName>B. L.</givenName>
      <familyName>Ndontsa</familyName>
      <affiliation>Univ Dschang, Dept Organ Chem, Fac Sci, Dschang, Cameroon</affiliation>
    </creator>
    <creator>
      <creatorName>Karaosmanoglu, O.</creatorName>
      <givenName>O.</givenName>
      <familyName>Karaosmanoglu</familyName>
    </creator>
    <creator>
      <creatorName>Weissjohann, L. A.</creatorName>
      <givenName>L. A.</givenName>
      <familyName>Weissjohann</familyName>
      <affiliation>Liebniz Inst Plant Biochem, Dept Biorgan Chem, Weinberg 3, D-06120 Halle, Saale, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Tane, P.</creatorName>
      <givenName>P.</givenName>
      <familyName>Tane</familyName>
      <affiliation>Univ Dschang, Dept Organ Chem, Fac Sci, Dschang, Cameroon</affiliation>
    </creator>
    <creator>
      <creatorName>Koparal, A. T.</creatorName>
      <givenName>A. T.</givenName>
      <familyName>Koparal</familyName>
      <affiliation>Anadolu Univ, Dept Biol, Sci Fac, Eskisehir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sivas, H.</creatorName>
      <givenName>H.</givenName>
      <familyName>Sivas</familyName>
      <affiliation>Anadolu Univ, Dept Biol, Sci Fac, Eskisehir, Turkey</affiliation>
    </creator>
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  <titles>
    <title>In Vitro Cytotoxicity Of Compounds Isolated From Desbordesia Glaucescens Against Human Carcinoma Cell Lines</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/111174</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.sajb.2017.03.031</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Malignancies constitute a global health concern and chemotherapy remains the main mode of treatment. The present study was designed to evaluate the cytotoxicity of 8 compounds from Desbordesia glaucescens namely lanosta-7,24-dien-3-one (1), friedelanone (2), friedelanol (3), 3,3'-di-O-methylellagic acid (4), 3,3',4'-tri-0-methylellagic acid (5), ellagic acid (6), 3',4'-di-0-methylellagic acid 4-0-beta-o-glucopyranoside (7) and 3,3'-di-0-methylellagic acid 4'-0-beta-c-xylopyranoside (8) against 4 human carcinoma cell lines and normal CRL2120 fibroblasts. The neutral red uptake (NRU) assay was used for cytotoxicity testing. Caspase-Glo assay, cell cycle analysis, measurements of mitochondrial membrane potential (MMP) and levels of reactive oxygen species (ROS) were used to evaluate apoptosis induction. Compounds 4 and 6 as well as doxorubicin had IC50 values below 45 pM in the four tested cancer cell lines meanwhile other compounds displayed selective activity. The IC50 values ranged from 11.23 mu M (towards breast adenocarcinoma MCF-7 cells) to 44.65 mu M (colon carcinoma Caco-2 cells) for 4, from 14.07 mu M (towards MCF-7 cells) to 77.73 mu M (Caco-2 cells) for 6 and from 0.07 mu M (towards SPC212 cells) to 1.01 mu M (A549 cells) for doxorubicin. Compound 4 induced apoptosis in MCF-7 cells mediated by MMP loss. The constituents of Desbordesia glaucescens and especially ellagic acid (6) and its derivative 4 are potential cytotoxic compounds that deserve more investigations towards developing novel antiproliferative drugs against human carcinoma. (C) 2017 SAAB. Published by Elsevier B.V. All rights reserved.</description>
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