1 Ocak 2017 Dergi makalesi Açık Erişim

Kuete, V.; Mafodong, F. L. Dongmo; Celik, I.; Fobofou, S. A. T.; Ndontsa, B. L.; Karaosmanoglu, O.; Weissjohann, L. A.; Tane, P.; Koparal, A. T.; Sivas, H.

JSON

{
  "conceptrecid": "111173", 
  "created": "2021-04-20T14:17:12.852641+00:00", 
  "doi": "10.1016/j.sajb.2017.03.031", 
  "files": [
    {
      "bucket": "b9f96290-a8e2-412c-a43f-f71d7a6594c8", 
      "checksum": "md5:a9e6587c19d2230ab33d2fba88732cc5", 
      "key": "bib-eb1960cf-9b47-465e-b2b0-cc0fb22ea3a1.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/b9f96290-a8e2-412c-a43f-f71d7a6594c8/bib-eb1960cf-9b47-465e-b2b0-cc0fb22ea3a1.txt"
      }, 
      "size": 299, 
      "type": "txt"
    }
  ], 
  "id": 111174, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.1016/j.sajb.2017.03.031.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/b9f96290-a8e2-412c-a43f-f71d7a6594c8", 
    "doi": "https://doi.org/10.1016/j.sajb.2017.03.031", 
    "html": "https://aperta.ulakbim.gov.tr/record/111174", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/111174", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/111174"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "name": "Kuete, V."
      }, 
      {
        "affiliation": "Univ Dschang, Dept Organ Chem, Fac Sci, Dschang, Cameroon", 
        "name": "Mafodong, F. L. Dongmo"
      }, 
      {
        "affiliation": "Anadolu Univ, Dept Chem, Fac Sci, Eskisehir, Turkey", 
        "name": "Celik, I."
      }, 
      {
        "name": "Fobofou, S. A. T."
      }, 
      {
        "affiliation": "Univ Dschang, Dept Organ Chem, Fac Sci, Dschang, Cameroon", 
        "name": "Ndontsa, B. L."
      }, 
      {
        "name": "Karaosmanoglu, O."
      }, 
      {
        "affiliation": "Liebniz Inst Plant Biochem, Dept Biorgan Chem, Weinberg 3, D-06120 Halle, Saale, Germany", 
        "name": "Weissjohann, L. A."
      }, 
      {
        "affiliation": "Univ Dschang, Dept Organ Chem, Fac Sci, Dschang, Cameroon", 
        "name": "Tane, P."
      }, 
      {
        "affiliation": "Anadolu Univ, Dept Biol, Sci Fac, Eskisehir, Turkey", 
        "name": "Koparal, A. T."
      }, 
      {
        "affiliation": "Anadolu Univ, Dept Biol, Sci Fac, Eskisehir, Turkey", 
        "name": "Sivas, H."
      }
    ], 
    "description": "Malignancies constitute a global health concern and chemotherapy remains the main mode of treatment. The present study was designed to evaluate the cytotoxicity of 8 compounds from Desbordesia glaucescens namely lanosta-7,24-dien-3-one (1), friedelanone (2), friedelanol (3), 3,3'-di-O-methylellagic acid (4), 3,3',4'-tri-0-methylellagic acid (5), ellagic acid (6), 3',4'-di-0-methylellagic acid 4-0-beta-o-glucopyranoside (7) and 3,3'-di-0-methylellagic acid 4'-0-beta-c-xylopyranoside (8) against 4 human carcinoma cell lines and normal CRL2120 fibroblasts. The neutral red uptake (NRU) assay was used for cytotoxicity testing. Caspase-Glo assay, cell cycle analysis, measurements of mitochondrial membrane potential (MMP) and levels of reactive oxygen species (ROS) were used to evaluate apoptosis induction. Compounds 4 and 6 as well as doxorubicin had IC50 values below 45 pM in the four tested cancer cell lines meanwhile other compounds displayed selective activity. The IC50 values ranged from 11.23 mu M (towards breast adenocarcinoma MCF-7 cells) to 44.65 mu M (colon carcinoma Caco-2 cells) for 4, from 14.07 mu M (towards MCF-7 cells) to 77.73 mu M (Caco-2 cells) for 6 and from 0.07 mu M (towards SPC212 cells) to 1.01 mu M (A549 cells) for doxorubicin. Compound 4 induced apoptosis in MCF-7 cells mediated by MMP loss. The constituents of Desbordesia glaucescens and especially ellagic acid (6) and its derivative 4 are potential cytotoxic compounds that deserve more investigations towards developing novel antiproliferative drugs against human carcinoma. (C) 2017 SAAB. Published by Elsevier B.V. All rights reserved.", 
    "doi": "10.1016/j.sajb.2017.03.031", 
    "has_grant": false, 
    "journal": {
      "pages": "37-43", 
      "title": "SOUTH AFRICAN JOURNAL OF BOTANY", 
      "volume": "111"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2017-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "111174"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "111173"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "In vitro cytotoxicity of compounds isolated from Desbordesia glaucescens against human carcinoma cell lines"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 3.0, 
    "unique_downloads": 3.0, 
    "unique_views": 9.0, 
    "version_downloads": 3.0, 
    "version_unique_downloads": 3.0, 
    "version_unique_views": 9.0, 
    "version_views": 11.0, 
    "version_volume": 897.0, 
    "views": 11.0, 
    "volume": 897.0
  }, 
  "updated": "2021-04-20T14:17:12.925329+00:00"
}