1 Ocak 2017 Dergi makalesi Açık Erişim

Kuete, V.; Mafodong, F. L. Dongmo; Celik, I.; Fobofou, S. A. T.; Ndontsa, B. L.; Karaosmanoglu, O.; Weissjohann, L. A.; Tane, P.; Koparal, A. T.; Sivas, H.

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      {
        "name": "Kuete, V."
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      {
        "affiliation": "Univ Dschang, Dept Organ Chem, Fac Sci, Dschang, Cameroon", 
        "name": "Mafodong, F. L. Dongmo"
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      {
        "affiliation": "Anadolu Univ, Dept Chem, Fac Sci, Eskisehir, Turkey", 
        "name": "Celik, I."
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      {
        "name": "Fobofou, S. A. T."
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      {
        "affiliation": "Univ Dschang, Dept Organ Chem, Fac Sci, Dschang, Cameroon", 
        "name": "Ndontsa, B. L."
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      {
        "name": "Karaosmanoglu, O."
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      {
        "affiliation": "Liebniz Inst Plant Biochem, Dept Biorgan Chem, Weinberg 3, D-06120 Halle, Saale, Germany", 
        "name": "Weissjohann, L. A."
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      {
        "affiliation": "Univ Dschang, Dept Organ Chem, Fac Sci, Dschang, Cameroon", 
        "name": "Tane, P."
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      {
        "affiliation": "Anadolu Univ, Dept Biol, Sci Fac, Eskisehir, Turkey", 
        "name": "Koparal, A. T."
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        "affiliation": "Anadolu Univ, Dept Biol, Sci Fac, Eskisehir, Turkey", 
        "name": "Sivas, H."
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    "description": "Malignancies constitute a global health concern and chemotherapy remains the main mode of treatment. The present study was designed to evaluate the cytotoxicity of 8 compounds from Desbordesia glaucescens namely lanosta-7,24-dien-3-one (1), friedelanone (2), friedelanol (3), 3,3'-di-O-methylellagic acid (4), 3,3',4'-tri-0-methylellagic acid (5), ellagic acid (6), 3',4'-di-0-methylellagic acid 4-0-beta-o-glucopyranoside (7) and 3,3'-di-0-methylellagic acid 4'-0-beta-c-xylopyranoside (8) against 4 human carcinoma cell lines and normal CRL2120 fibroblasts. The neutral red uptake (NRU) assay was used for cytotoxicity testing. Caspase-Glo assay, cell cycle analysis, measurements of mitochondrial membrane potential (MMP) and levels of reactive oxygen species (ROS) were used to evaluate apoptosis induction. Compounds 4 and 6 as well as doxorubicin had IC50 values below 45 pM in the four tested cancer cell lines meanwhile other compounds displayed selective activity. The IC50 values ranged from 11.23 mu M (towards breast adenocarcinoma MCF-7 cells) to 44.65 mu M (colon carcinoma Caco-2 cells) for 4, from 14.07 mu M (towards MCF-7 cells) to 77.73 mu M (Caco-2 cells) for 6 and from 0.07 mu M (towards SPC212 cells) to 1.01 mu M (A549 cells) for doxorubicin. Compound 4 induced apoptosis in MCF-7 cells mediated by MMP loss. The constituents of Desbordesia glaucescens and especially ellagic acid (6) and its derivative 4 are potential cytotoxic compounds that deserve more investigations towards developing novel antiproliferative drugs against human carcinoma. (C) 2017 SAAB. Published by Elsevier B.V. All rights reserved.", 
    "doi": "10.1016/j.sajb.2017.03.031", 
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    "journal": {
      "pages": "37-43", 
      "title": "SOUTH AFRICAN JOURNAL OF BOTANY", 
      "volume": "111"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2017-01-01", 
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    "title": "In vitro cytotoxicity of compounds isolated from Desbordesia glaucescens against human carcinoma cell lines"
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