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In Vitro Evaluation of Electrospun Polysaccharide Based Nanofibrous Mats as Surgical Adhesion Barriers

Safak, Serife; Vatan, Ozgur; Cinkilic, Nilufer; Karaca, Esra


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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Safak, Serife</dc:creator>
  <dc:creator>Vatan, Ozgur</dc:creator>
  <dc:creator>Cinkilic, Nilufer</dc:creator>
  <dc:creator>Karaca, Esra</dc:creator>
  <dc:date>2020-01-01</dc:date>
  <dc:description>Post-operative adhesions are one of the most important problems faced by patients and surgeons. In this study, nanofibrous mats were produced as novel surgical adhesion barrier from polysaccharide-based polymers, hyaluronic acid, carboxymethyl cellulose and sodium alginate, via electrospinning. The produced nanofibrous mats were crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysulfosuccinimide. Furthermore, the morphology, in vitro degradation, cytotoxicity and cell adherence potentials of the nanofibrous mats aimed to be used as adhesion barriers were evaluated and compared with a commercial adhesion barrier. Results of the in vitro experiment showed that the nanofibrous mats have maintained their physical structures during the critical period for adhesion formation, and had non-adherent cell feature and non-cytotoxic nature required for an ideal adhesion barrier.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/9969</dc:identifier>
  <dc:identifier>oai:zenodo.org:9969</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>TEKSTIL VE KONFEKSIYON 30(2) 99-107</dc:source>
  <dc:title>In Vitro Evaluation of Electrospun Polysaccharide Based Nanofibrous Mats as Surgical Adhesion Barriers</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>
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