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In Vitro Evaluation of Electrospun Polysaccharide Based Nanofibrous Mats as Surgical Adhesion Barriers

Safak, Serife; Vatan, Ozgur; Cinkilic, Nilufer; Karaca, Esra


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{
  "DOI": "10.32710/tekstilvekonfeksiyon.548460", 
  "abstract": "Post-operative adhesions are one of the most important problems faced by patients and surgeons. In this study, nanofibrous mats were produced as novel surgical adhesion barrier from polysaccharide-based polymers, hyaluronic acid, carboxymethyl cellulose and sodium alginate, via electrospinning. The produced nanofibrous mats were crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysulfosuccinimide. Furthermore, the morphology, in vitro degradation, cytotoxicity and cell adherence potentials of the nanofibrous mats aimed to be used as adhesion barriers were evaluated and compared with a commercial adhesion barrier. Results of the in vitro experiment showed that the nanofibrous mats have maintained their physical structures during the critical period for adhesion formation, and had non-adherent cell feature and non-cytotoxic nature required for an ideal adhesion barrier.", 
  "author": [
    {
      "family": "Safak", 
      "given": " Serife"
    }, 
    {
      "family": "Vatan", 
      "given": " Ozgur"
    }, 
    {
      "family": "Cinkilic", 
      "given": " Nilufer"
    }, 
    {
      "family": "Karaca", 
      "given": " Esra"
    }
  ], 
  "container_title": "TEKSTIL VE KONFEKSIYON", 
  "id": "9969", 
  "issue": "2", 
  "issued": {
    "date-parts": [
      [
        2020, 
        1, 
        1
      ]
    ]
  }, 
  "page": "99-107", 
  "title": "In Vitro Evaluation of Electrospun Polysaccharide Based Nanofibrous Mats as Surgical Adhesion Barriers", 
  "type": "article-journal", 
  "volume": "30"
}
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