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In Vitro Evaluation of Electrospun Polysaccharide Based Nanofibrous Mats as Surgical Adhesion Barriers

Safak, Serife; Vatan, Ozgur; Cinkilic, Nilufer; Karaca, Esra


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{
  "@context": "https://schema.org/", 
  "@id": 9969, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Namik Kemal Univ, Corlu Fac Engn, Dept Text Engn, TR-59860 Corlu, Tekirdag, Turkey", 
      "name": "Safak, Serife"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Uludag Univ, Fac Arts & Sci, Dept Biol, TR-16059 Bursa, Turkey", 
      "name": "Vatan, Ozgur"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Uludag Univ, Fac Arts & Sci, Dept Biol, TR-16059 Bursa, Turkey", 
      "name": "Cinkilic, Nilufer"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Uludag Univ, Fac Engn, Dept Text Engn, TR-16059 Bursa, Turkey", 
      "name": "Karaca, Esra"
    }
  ], 
  "datePublished": "2020-01-01", 
  "description": "Post-operative adhesions are one of the most important problems faced by patients and surgeons. In this study, nanofibrous mats were produced as novel surgical adhesion barrier from polysaccharide-based polymers, hyaluronic acid, carboxymethyl cellulose and sodium alginate, via electrospinning. The produced nanofibrous mats were crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysulfosuccinimide. Furthermore, the morphology, in vitro degradation, cytotoxicity and cell adherence potentials of the nanofibrous mats aimed to be used as adhesion barriers were evaluated and compared with a commercial adhesion barrier. Results of the in vitro experiment showed that the nanofibrous mats have maintained their physical structures during the critical period for adhesion formation, and had non-adherent cell feature and non-cytotoxic nature required for an ideal adhesion barrier.", 
  "headline": "In Vitro Evaluation of Electrospun Polysaccharide Based Nanofibrous Mats as Surgical Adhesion Barriers", 
  "identifier": 9969, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "In Vitro Evaluation of Electrospun Polysaccharide Based Nanofibrous Mats as Surgical Adhesion Barriers", 
  "url": "https://aperta.ulakbim.gov.tr/record/9969"
}
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