1 Ocak 2017 Dergi makalesi Açık Erişim

Alpaslan, Ece; Geilich, Benjamin M.; Yazici, Hilal; Webster, Thomas J.

Dublin Core

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  <dc:creator>Alpaslan, Ece</dc:creator>
  <dc:creator>Geilich, Benjamin M.</dc:creator>
  <dc:creator>Yazici, Hilal</dc:creator>
  <dc:creator>Webster, Thomas J.</dc:creator>
  <dc:date>2017-01-01</dc:date>
  <dc:description>Here, the antibacterial activity of dextran-coated nanoceria was examined against Pseudomonas aeruginosa and Staphylococcus epidermidis by varying the dose, the time of treatment, and the pH of the solution. Findings suggested that dextran-coated nanoceria particles were much more effective at killing P. aeruginosa and S. epidermidis at basic pH values (pH = 9) compared to acidic pH values (pH = 6) due to a smaller size and positive surface charge at pH 9. At pH 9, different particle concentrations did cause a delay in the growth of P. aeruginosa, whereas impressively S. epidermidis did not grow at all when treated with a 500 mu g/mL nanoceria concentration for 24 hours. For both bacteria, a 2 log reduction and elevated amounts of reactive oxygen species (ROS) generation per colony were observed after 6 hours of treatment with nanoceria at pH 9 compared to untreated controls. After 6 hours of incubation with nanoceria at pH 9, P. aeruginosa showed drastic morphological changes as a result of cellular stress. In summary, this study provides significant evidence for the use of nanoceria (+4) for a wide range of anti-infection applications without resorting to the use of antibiotics, for which bacteria are developing a resistance towards anyway.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/98353</dc:identifier>
  <dc:identifier>oai:zenodo.org:98353</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>SCIENTIFIC REPORTS 7</dc:source>
  <dc:title>pH-Controlled Cerium Oxide Nanoparticle Inhibition of Both Gram-Positive and Gram-Negative Bacteria Growth</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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