1 Ocak 2017 Dergi makalesi Açık Erişim

Alpaslan, Ece; Geilich, Benjamin M.; Yazici, Hilal; Webster, Thomas J.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/98353</identifier>
  <creators>
    <creator>
      <creatorName>Alpaslan, Ece</creatorName>
      <givenName>Ece</givenName>
      <familyName>Alpaslan</familyName>
      <affiliation>Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Geilich, Benjamin M.</creatorName>
      <givenName>Benjamin M.</givenName>
      <familyName>Geilich</familyName>
      <affiliation>Northeastern Univ, Dept Bioengn, Boston, MA 02115 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Yazici, Hilal</creatorName>
      <givenName>Hilal</givenName>
      <familyName>Yazici</familyName>
    </creator>
    <creator>
      <creatorName>Webster, Thomas J.</creatorName>
      <givenName>Thomas J.</givenName>
      <familyName>Webster</familyName>
    </creator>
  </creators>
  <titles>
    <title>Ph-Controlled Cerium Oxide Nanoparticle Inhibition Of Both Gram-Positive And Gram-Negative Bacteria Growth</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/98353</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1038/srep45859</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Here, the antibacterial activity of dextran-coated nanoceria was examined against Pseudomonas aeruginosa and Staphylococcus epidermidis by varying the dose, the time of treatment, and the pH of the solution. Findings suggested that dextran-coated nanoceria particles were much more effective at killing P. aeruginosa and S. epidermidis at basic pH values (pH = 9) compared to acidic pH values (pH = 6) due to a smaller size and positive surface charge at pH 9. At pH 9, different particle concentrations did cause a delay in the growth of P. aeruginosa, whereas impressively S. epidermidis did not grow at all when treated with a 500 mu g/mL nanoceria concentration for 24 hours. For both bacteria, a 2 log reduction and elevated amounts of reactive oxygen species (ROS) generation per colony were observed after 6 hours of treatment with nanoceria at pH 9 compared to untreated controls. After 6 hours of incubation with nanoceria at pH 9, P. aeruginosa showed drastic morphological changes as a result of cellular stress. In summary, this study provides significant evidence for the use of nanoceria (+4) for a wide range of anti-infection applications without resorting to the use of antibiotics, for which bacteria are developing a resistance towards anyway.</description>
  </descriptions>
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