1 Ocak 2018 Dergi makalesi Açık Erişim

Vardar, Deniz Ozkan; Aydin, Sevtap; Hocaoglu, Ibrahim; Acar, Funda Havva Yagci; Basaran, Nursen

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/89793</identifier>
  <creators>
    <creator>
      <creatorName>Vardar, Deniz Ozkan</creatorName>
      <givenName>Deniz Ozkan</givenName>
      <familyName>Vardar</familyName>
      <affiliation>Hitit Univ, Sungurlu Vocat High Sch, Hlth Programs, Sungurlu, Corum, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aydin, Sevtap</creatorName>
      <givenName>Sevtap</givenName>
      <familyName>Aydin</familyName>
      <affiliation>Hacettepe Univ, Dept Toxicol, Fac Pharm, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Hocaoglu, Ibrahim</creatorName>
      <givenName>Ibrahim</givenName>
      <familyName>Hocaoglu</familyName>
      <affiliation>TUBITAK Marmara Res Ctr, Genet Engn &amp; Biotechnol Inst, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Acar, Funda Havva Yagci</creatorName>
      <givenName>Funda Havva Yagci</givenName>
      <familyName>Acar</familyName>
      <affiliation>Koc Univ, Dept Chem, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Basaran, Nursen</creatorName>
      <givenName>Nursen</givenName>
      <familyName>Basaran</familyName>
      <affiliation>Hacettepe Univ, Dept Toxicol, Fac Pharm, Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Effects Of Silver Sulfide Quantum Dots Coated With 2-Mercaptopropionic Acid On Genotoxic And Apoptotic Pathways In Vitro</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2018</publicationYear>
  <dates>
    <date dateType="Issued">2018-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/89793</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.cbi.2018.06.032</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Quantum dots (QDs) are highly promising nanomaterials in bioimaging system because of their bright fluorescence, broad UV excitation, narrow emission band, and high photostability. Recently, there is a great activity on Ag2S quantum dots for both imaging and drug/gene delivery due to the potential of having a better cytocompatability and near infrared luminescence. 2-Mercaptopropionic acid (2 MP A)-coated silver sulfide (Ag2S) QDs were reported as the most luminescent, stable, anionic Ag2S QDs in the literature. In this study, we aim to determine the cytotoxicity of 2 MP A/Ag2S in Chinese hamster lung fibroblast (V79) cells. The genotoxic and apoptotic effects of 2 MP A/Ag2S QDs were assessed by the alkaline single cell electrophoresis assay and real time polymerase chain reaction techniques, respectively. The cell viability decreased above 200 mu g/ml and 800 mu g/ml for MTT tetrazolium and neural red uptake assays, respectively. DNA damage was not observed by 2 MP A/Ag2S QDs at the studied concentration levels (5-2000 mu g/ml). The levels of mRNA expression of p53, caspase 3, caspase 9, box, bcl-2, survivin were not changed by 2 MP A/Ag2S QDs below IC50 (around 1000 mu g/ml). Hence, 2 MP A/Ag2S QDs did not show any cytotoxic or genotoxic effects in V79 cells at lower doses. We conclude that the biocompatibility of 2 MP A/Ag2S ODs makes them suitable for cell labeling applications.</description>
  </descriptions>
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