1 Ocak 2015 Dergi makalesi Açık Erişim

Kip, Cigdem; Erkakan, Damla; Gokaltun, Aslihan; Celebi, Bekir; Tuncel, Ali

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/82947</identifier>
  <creators>
    <creator>
      <creatorName>Kip, Cigdem</creatorName>
      <givenName>Cigdem</givenName>
      <familyName>Kip</familyName>
      <affiliation>Hacettepe Univ, Dept Chem Engn, TR-06532 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Erkakan, Damla</creatorName>
      <givenName>Damla</givenName>
      <familyName>Erkakan</familyName>
      <affiliation>Hacettepe Univ, Dept Chem Engn, TR-06532 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gokaltun, Aslihan</creatorName>
      <givenName>Aslihan</givenName>
      <familyName>Gokaltun</familyName>
      <affiliation>Hacettepe Univ, Dept Chem Engn, TR-06532 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Celebi, Bekir</creatorName>
      <givenName>Bekir</givenName>
      <familyName>Celebi</familyName>
      <affiliation>Hacettepe Univ, Dept Chem Engn, TR-06532 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tuncel, Ali</creatorName>
      <givenName>Ali</givenName>
      <familyName>Tuncel</familyName>
    </creator>
  </creators>
  <titles>
    <title>Synthesis Of A Reactive Polymethacrylate Capillary Monolith And Its Use As A Starting Material For The Preparation Of A Stationary Phase For Hydrophilic Interaction Chromatography</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2015</publicationYear>
  <dates>
    <date dateType="Issued">2015-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/82947</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.chroma.2015.04.005</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Poly(3-chloro-2-hydroxypropyl methacrylate-co-ethylene dimethacrylate), poly(HPMA-Cl-co-EDMA) capillary monolith was proposed as a reactive starting material with tailoring flexibility for the preparation of monolithic stationary phases. The reactive capillary monolith was synthesized by free radical copolymerization of 3-chloro-2-hydroxypropyl methacrylate (HPMA-Cl) and ethylene dimethacrylate (EDMA). The mean pore size, the specific surface area and the permeability of poly(HPMA-Cl-co-EDMA) monoliths were controlled by adjusting porogen/monomer volume ratio, porogen composition and polymerization temperature. The porogen/monomer volume ratio was found as the most effective factor controlling the porous properties of poly(HPMA-Cl-co-EDMA) monolith. Triethanolamine (TEA-OH) functionalized polymethacrylate monoliths were prepared by using the reactive chloropropyl group of poly(HPMA-Cl-co-EDMA) monolith via one-pot and simple post-functionalization process. Poly(HPMA-Cl-co-EDMA) monolith reacted with TEA-OH was evaluated as a stationary phase in nano-hydrophilic interaction chromatography (nano-HILIC). Nucleotides, nucleosides and benzoic acid derivatives were satisfactorily separated with the plate heights up to 20 mu m. TEA-OH attached-poly(HPMA-Cl-co-EDIVIA) monolith showed a reproducible and stable retention behaviour in nano-HILIC runs. However, a decrease in the column performance (i.e. an increase in the plate height) was observed with the increasing retention factor. Hence "retention-dependent column efficiency" behaviour was shown for HILIC mode using the chromatographic data collected with the polymer based monolith synthesized. (C) 2015 Elsevier B.V. All rights reserved.</description>
  </descriptions>
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