Dergi makalesi Açık Erişim

Oxidation of aminoalkyl and hydroxylaminoalkyl furans

Kazancioglu, Mustafa Zahrittin; Kazancioglu, Elif Akin; Secen, Hasan; Altundas, Ramazan


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        "affiliation": "Ataturk Univ, Dept Chem, Coll Sci, TR-25240 Erzurum, Turkey", 
        "name": "Kazancioglu, Mustafa Zahrittin"
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        "affiliation": "Ataturk Univ, Dept Chem, Coll Sci, TR-25240 Erzurum, Turkey", 
        "name": "Kazancioglu, Elif Akin"
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        "affiliation": "Ataturk Univ, Dept Chem, Coll Sci, TR-25240 Erzurum, Turkey", 
        "name": "Secen, Hasan"
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        "affiliation": "Ataturk Univ, Dept Chem, Coll Sci, TR-25240 Erzurum, Turkey", 
        "name": "Altundas, Ramazan"
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    "description": "The oxidation reactions of amino and hydroxylamino substituted alkylfurans were explored for the synthesis of structurally complex compounds from simple starting materials. A novel photooxygenation of the furan derivatives gave an alpha,beta-unsaturated dicarbonyl moiety which underwent subsequent conjugate addition to yield diastereomeric mixtures of the corresponding pyrrolidine and isoxazoline heterocycles. Oxidation of the alpha,beta-unsaturated dicarbonyl using mCPBA gave epoxide intermediates, which were opened by nucleophilic attack of the amino groups, furnishing pyrrolidine and isoxazolidine heterocycles. (C) 2015 Elsevier Ltd. All rights reserved.", 
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