1 Ocak 2015 Dergi makalesi Açık Erişim

Lenkey, Nora; Kirizs, Tekla; Holderith, Noemi; Mate, Zoltan; Szabo, Gabor; Vizi, E. Sylvester; Hajos, Norbert; Nusser, Zoltan

Dublin Core

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  <dc:creator>Lenkey, Nora</dc:creator>
  <dc:creator>Kirizs, Tekla</dc:creator>
  <dc:creator>Holderith, Noemi</dc:creator>
  <dc:creator>Mate, Zoltan</dc:creator>
  <dc:creator>Szabo, Gabor</dc:creator>
  <dc:creator>Vizi, E. Sylvester</dc:creator>
  <dc:creator>Hajos, Norbert</dc:creator>
  <dc:creator>Nusser, Zoltan</dc:creator>
  <dc:date>2015-01-01</dc:date>
  <dc:description>The release of GABA from cholecystokinin-containing interneurons is modulated by type-1 cannabinoid receptors (CB1). Here we tested the hypothesis that the strength of CB1-mediated modulation of GABA release is related to the CB1 content of axon terminals. Basket cell boutons have on average 78% higher CB1 content than those of dendritic-layer-innervating (DLI) cells, a consequence of larger bouton surface and higher CB1 density. The CB1 antagonist AM251 caused a 54% increase in action potential-evoked [Ca2+] in boutons of basket cells, but not in DLI cells. However, the effect of AM251 did not correlate with CB1 immunoreactivity of individual boutons. Moreover, a CB1 agonist decreased [Ca2+] in a cell type-and CB1-content-independent manner. Replica immunogold labelling demonstrated the colocalization of CB1 with the Cav2.2 Ca2+ channel subunit. Our data suggest that only a subpopulation of CB(1)s, within nanometre distances from their target Cav2.2 channels, are responsible for endocannabinoid-mediated modulation of GABA release.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/81947</dc:identifier>
  <dc:identifier>oai:zenodo.org:81947</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>NATURE COMMUNICATIONS 6</dc:source>
  <dc:title>Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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