1 Ocak 2015 Dergi makalesi Açık Erişim

Lenkey, Nora; Kirizs, Tekla; Holderith, Noemi; Mate, Zoltan; Szabo, Gabor; Vizi, E. Sylvester; Hajos, Norbert; Nusser, Zoltan

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        "affiliation": "Hungarian Acad Sci, Inst Expt Med, Lendulet Lab Cellular Neurophysiol, H-1083 Budapest, Hungary", 
        "name": "Lenkey, Nora"
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      {
        "name": "Kirizs, Tekla"
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      {
        "affiliation": "Hungarian Acad Sci, Inst Expt Med, Lendulet Lab Cellular Neurophysiol, H-1083 Budapest, Hungary", 
        "name": "Holderith, Noemi"
      }, 
      {
        "affiliation": "Hungarian Acad Sci, Inst Expt Med, Div Med Gene Technol, H-1083 Budapest, Hungary", 
        "name": "Mate, Zoltan"
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      {
        "affiliation": "Hungarian Acad Sci, Inst Expt Med, Div Med Gene Technol, H-1083 Budapest, Hungary", 
        "name": "Szabo, Gabor"
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      {
        "affiliation": "Hungarian Acad Sci, Inst Expt Med, Lab Drug Res, H-1083 Budapest, Hungary", 
        "name": "Vizi, E. Sylvester"
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      {
        "affiliation": "Hungarian Acad Sci, Inst Expt Med, Lendulet Lab Network Neurophysiol, H-1083 Budapest, Hungary", 
        "name": "Hajos, Norbert"
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      {
        "affiliation": "Hungarian Acad Sci, Inst Expt Med, Lendulet Lab Cellular Neurophysiol, H-1083 Budapest, Hungary", 
        "name": "Nusser, Zoltan"
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    ], 
    "description": "The release of GABA from cholecystokinin-containing interneurons is modulated by type-1 cannabinoid receptors (CB1). Here we tested the hypothesis that the strength of CB1-mediated modulation of GABA release is related to the CB1 content of axon terminals. Basket cell boutons have on average 78% higher CB1 content than those of dendritic-layer-innervating (DLI) cells, a consequence of larger bouton surface and higher CB1 density. The CB1 antagonist AM251 caused a 54% increase in action potential-evoked [Ca2+] in boutons of basket cells, but not in DLI cells. However, the effect of AM251 did not correlate with CB1 immunoreactivity of individual boutons. Moreover, a CB1 agonist decreased [Ca2+] in a cell type-and CB1-content-independent manner. Replica immunogold labelling demonstrated the colocalization of CB1 with the Cav2.2 Ca2+ channel subunit. Our data suggest that only a subpopulation of CB(1)s, within nanometre distances from their target Cav2.2 channels, are responsible for endocannabinoid-mediated modulation of GABA release.", 
    "doi": "10.1038/ncomms7557", 
    "has_grant": false, 
    "journal": {
      "title": "NATURE COMMUNICATIONS", 
      "volume": "6"
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    "publication_date": "2015-01-01", 
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      "title": "Dergi makalesi", 
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    "title": "Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals"
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