1 Ocak 2015 Dergi makalesi Açık Erişim

Lenkey, Nora; Kirizs, Tekla; Holderith, Noemi; Mate, Zoltan; Szabo, Gabor; Vizi, E. Sylvester; Hajos, Norbert; Nusser, Zoltan

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{
  "@context": "https://schema.org/", 
  "@id": 81947, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Hungarian Acad Sci, Inst Expt Med, Lendulet Lab Cellular Neurophysiol, H-1083 Budapest, Hungary", 
      "name": "Lenkey, Nora"
    }, 
    {
      "@type": "Person", 
      "name": "Kirizs, Tekla"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hungarian Acad Sci, Inst Expt Med, Lendulet Lab Cellular Neurophysiol, H-1083 Budapest, Hungary", 
      "name": "Holderith, Noemi"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hungarian Acad Sci, Inst Expt Med, Div Med Gene Technol, H-1083 Budapest, Hungary", 
      "name": "Mate, Zoltan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hungarian Acad Sci, Inst Expt Med, Div Med Gene Technol, H-1083 Budapest, Hungary", 
      "name": "Szabo, Gabor"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hungarian Acad Sci, Inst Expt Med, Lab Drug Res, H-1083 Budapest, Hungary", 
      "name": "Vizi, E. Sylvester"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hungarian Acad Sci, Inst Expt Med, Lendulet Lab Network Neurophysiol, H-1083 Budapest, Hungary", 
      "name": "Hajos, Norbert"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hungarian Acad Sci, Inst Expt Med, Lendulet Lab Cellular Neurophysiol, H-1083 Budapest, Hungary", 
      "name": "Nusser, Zoltan"
    }
  ], 
  "datePublished": "2015-01-01", 
  "description": "The release of GABA from cholecystokinin-containing interneurons is modulated by type-1 cannabinoid receptors (CB1). Here we tested the hypothesis that the strength of CB1-mediated modulation of GABA release is related to the CB1 content of axon terminals. Basket cell boutons have on average 78% higher CB1 content than those of dendritic-layer-innervating (DLI) cells, a consequence of larger bouton surface and higher CB1 density. The CB1 antagonist AM251 caused a 54% increase in action potential-evoked [Ca2+] in boutons of basket cells, but not in DLI cells. However, the effect of AM251 did not correlate with CB1 immunoreactivity of individual boutons. Moreover, a CB1 agonist decreased [Ca2+] in a cell type-and CB1-content-independent manner. Replica immunogold labelling demonstrated the colocalization of CB1 with the Cav2.2 Ca2+ channel subunit. Our data suggest that only a subpopulation of CB(1)s, within nanometre distances from their target Cav2.2 channels, are responsible for endocannabinoid-mediated modulation of GABA release.", 
  "headline": "Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals", 
  "identifier": 81947, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals", 
  "url": "https://aperta.ulakbim.gov.tr/record/81947"
}