1 Ocak 2015 Dergi makalesi Açık Erişim

Tekarslan, S. Hande; Alkim, Ceren; Hunte, Carola; Cakar, Z. Petek

Dublin Core

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  <dc:creator>Tekarslan, S. Hande</dc:creator>
  <dc:creator>Alkim, Ceren</dc:creator>
  <dc:creator>Hunte, Carola</dc:creator>
  <dc:creator>Cakar, Z. Petek</dc:creator>
  <dc:date>2015-01-01</dc:date>
  <dc:description>The yeast Saccharomyces cerevisiae is a simple eukaryote and an excellent model organism for molecular biology. In this study, a NaCl-resistant S. cerevisiae mutant obtained by inverse metabolic engineering was used as a model to investigate responses and resistance behavior to NaCl, LiCl, KCl, TMA, spermine and sorbitol stresses., at physiological and genetic levels. The physiological spot test results revealed that the NaCl-resistant yeast mutant showed higher resistance to LiCl and NaCl. Gene expression analysis by qRT-PCR revealed that ENA6 and NHA1 genes of the mutant were induced in the absence and presence of LiCl and NaCl. The dysfunction of Na+/H+ antiporters are related to several diseases such as hypertension, epilepsy, postischemic myocardial arrhythmia, gastric and kidney disease, diarrhea, and glaucoma. Thus, the NaCl-resistant yeast mutant could be used to understand cellular sodium and lithium resistance mechanisms and the function of Na+/H+ antiporters also in higher eukaryotic organisms, including humans.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/81321</dc:identifier>
  <dc:identifier>oai:zenodo.org:81321</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>ISTANBUL JOURNAL OF PHARMACY 45(2) 165-179</dc:source>
  <dc:title>Physiological and genetic analysis of cellular sodium and lithium response/resistance behavior using the yeast Saccharomyces cerevisiae as a model organism</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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