1 Ocak 2015 Dergi makalesi Açık Erişim

Tekarslan, S. Hande; Alkim, Ceren; Hunte, Carola; Cakar, Z. Petek

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/81321</identifier>
  <creators>
    <creator>
      <creatorName>Tekarslan, S. Hande</creatorName>
      <givenName>S. Hande</givenName>
      <familyName>Tekarslan</familyName>
    </creator>
    <creator>
      <creatorName>Alkim, Ceren</creatorName>
      <givenName>Ceren</givenName>
      <familyName>Alkim</familyName>
    </creator>
    <creator>
      <creatorName>Hunte, Carola</creatorName>
      <givenName>Carola</givenName>
      <familyName>Hunte</familyName>
      <affiliation>Univ Freiburg, BIOSS Ctr Biol Signalling Studies, Inst Biochem &amp; Mol Biol, ZBMZ, Freiburg, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Cakar, Z. Petek</creatorName>
      <givenName>Z. Petek</givenName>
      <familyName>Cakar</familyName>
    </creator>
  </creators>
  <titles>
    <title>Physiological And Genetic Analysis Of Cellular Sodium And Lithium Response/Resistance Behavior Using The Yeast Saccharomyces Cerevisiae As A Model Organism</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2015</publicationYear>
  <dates>
    <date dateType="Issued">2015-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/81321</alternateIdentifier>
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    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.81043/aperta.81320</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.81043/aperta.81321</relatedIdentifier>
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  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The yeast Saccharomyces cerevisiae is a simple eukaryote and an excellent model organism for molecular biology. In this study, a NaCl-resistant S. cerevisiae mutant obtained by inverse metabolic engineering was used as a model to investigate responses and resistance behavior to NaCl, LiCl, KCl, TMA, spermine and sorbitol stresses., at physiological and genetic levels. The physiological spot test results revealed that the NaCl-resistant yeast mutant showed higher resistance to LiCl and NaCl. Gene expression analysis by qRT-PCR revealed that ENA6 and NHA1 genes of the mutant were induced in the absence and presence of LiCl and NaCl. The dysfunction of Na+/H+ antiporters are related to several diseases such as hypertension, epilepsy, postischemic myocardial arrhythmia, gastric and kidney disease, diarrhea, and glaucoma. Thus, the NaCl-resistant yeast mutant could be used to understand cellular sodium and lithium resistance mechanisms and the function of Na+/H+ antiporters also in higher eukaryotic organisms, including humans.</description>
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