1 Ocak 2015 Dergi makalesi Açık Erişim

Tekarslan, S. Hande; Alkim, Ceren; Hunte, Carola; Cakar, Z. Petek

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        "name": "Tekarslan, S. Hande"
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      {
        "name": "Alkim, Ceren"
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        "affiliation": "Univ Freiburg, BIOSS Ctr Biol Signalling Studies, Inst Biochem & Mol Biol, ZBMZ, Freiburg, Germany", 
        "name": "Hunte, Carola"
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        "name": "Cakar, Z. Petek"
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    "description": "The yeast Saccharomyces cerevisiae is a simple eukaryote and an excellent model organism for molecular biology. In this study, a NaCl-resistant S. cerevisiae mutant obtained by inverse metabolic engineering was used as a model to investigate responses and resistance behavior to NaCl, LiCl, KCl, TMA, spermine and sorbitol stresses., at physiological and genetic levels. The physiological spot test results revealed that the NaCl-resistant yeast mutant showed higher resistance to LiCl and NaCl. Gene expression analysis by qRT-PCR revealed that ENA6 and NHA1 genes of the mutant were induced in the absence and presence of LiCl and NaCl. The dysfunction of Na+/H+ antiporters are related to several diseases such as hypertension, epilepsy, postischemic myocardial arrhythmia, gastric and kidney disease, diarrhea, and glaucoma. Thus, the NaCl-resistant yeast mutant could be used to understand cellular sodium and lithium resistance mechanisms and the function of Na+/H+ antiporters also in higher eukaryotic organisms, including humans.", 
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      "issue": "2", 
      "pages": "165-179", 
      "title": "ISTANBUL JOURNAL OF PHARMACY", 
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    "title": "Physiological and genetic analysis of cellular sodium and lithium response/resistance behavior using the yeast Saccharomyces cerevisiae as a model organism"
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