1 Ocak 2015 Dergi makalesi Açık Erişim

Tekarslan, S. Hande; Alkim, Ceren; Hunte, Carola; Cakar, Z. Petek

Citation Style Language JSON

{
  "URL": "https://aperta.ulakbim.gov.tr/record/81321", 
  "abstract": "The yeast Saccharomyces cerevisiae is a simple eukaryote and an excellent model organism for molecular biology. In this study, a NaCl-resistant S. cerevisiae mutant obtained by inverse metabolic engineering was used as a model to investigate responses and resistance behavior to NaCl, LiCl, KCl, TMA, spermine and sorbitol stresses., at physiological and genetic levels. The physiological spot test results revealed that the NaCl-resistant yeast mutant showed higher resistance to LiCl and NaCl. Gene expression analysis by qRT-PCR revealed that ENA6 and NHA1 genes of the mutant were induced in the absence and presence of LiCl and NaCl. The dysfunction of Na+/H+ antiporters are related to several diseases such as hypertension, epilepsy, postischemic myocardial arrhythmia, gastric and kidney disease, diarrhea, and glaucoma. Thus, the NaCl-resistant yeast mutant could be used to understand cellular sodium and lithium resistance mechanisms and the function of Na+/H+ antiporters also in higher eukaryotic organisms, including humans.", 
  "author": [
    {
      "family": "Tekarslan", 
      "given": " S. Hande"
    }, 
    {
      "family": "Alkim", 
      "given": " Ceren"
    }, 
    {
      "family": "Hunte", 
      "given": " Carola"
    }, 
    {
      "family": "Cakar", 
      "given": " Z. Petek"
    }
  ], 
  "container_title": "ISTANBUL JOURNAL OF PHARMACY", 
  "id": "81321", 
  "issue": "2", 
  "issued": {
    "date-parts": [
      [
        2015, 
        1, 
        1
      ]
    ]
  }, 
  "page": "165-179", 
  "title": "Physiological and genetic analysis of cellular sodium and lithium response/resistance behavior using the yeast Saccharomyces cerevisiae as a model organism", 
  "type": "article-journal", 
  "volume": "45"
}