1 Ocak 2015 Dergi makalesi Açık Erişim

Alahgholi-Hajibehzad, Mandi; Oflazer, Piraye; Aysal, Fikret; Durmus, Hacer; Gulsen-Parman, Yesim; Marx, Alexander; Deymeer, Feza; Saruhan-Direskeneli, Guher

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  "@id": 79097, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Alahgholi-Hajibehzad, Mandi"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
      "name": "Oflazer, Piraye"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bakirkoy Res & Training Hosp Psychiat & Neurol Di, Dept Neurol, Istanbul, Turkey", 
      "name": "Aysal, Fikret"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
      "name": "Durmus, Hacer"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
      "name": "Gulsen-Parman, Yesim"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Heidelberg Univ, Univ Med Ctr Mannheim, Inst Pathol, Mannheim, Germany", 
      "name": "Marx, Alexander"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
      "name": "Deymeer, Feza"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Dept Physiol, Istanbul Med Fac, Istanbul, Turkey", 
      "name": "Saruhan-Direskeneli, Guher"
    }
  ], 
  "datePublished": "2015-01-01", 
  "description": "Regulatory T cells were investigated in early-onset (EO) and late-onset (LO) myasthenia gravis patients with anti-acetylcholine receptor antibody (AChR-MG). Alterations in PD-1 and PD-L1 on CD4(+)CD25(++) (Treg) and responder T cells (Tresp, CD4(+)CD25(-)) were observed in LOMG patients. GITR was decreased on CD4(+)CD25(++) of all patients. Decrease of FOXP3 was associated with lower phosphorylation of STAT5.1,25-dihydroxyvitamin D3 (VitD3) increased suppression in co-culture with a stronger effect in patients by acting possibly both on cell groups. Changes in surface molecules and intracellular pathways contribute to the defects of Treg in non-thymomatous AChR-MG and VitD3 can have modulatory effects. (C) 2015 Elsevier B.V. All rights reserved.", 
  "headline": "Regulatory function of CD4(+)CD25(++) T cells in patients with myasthenia gravis is associated with phenotypic changes and STAT5 signaling: 1,25-Dihydroxyvitamin D3 modulates the suppressor activity", 
  "identifier": 79097, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Regulatory function of CD4(+)CD25(++) T cells in patients with myasthenia gravis is associated with phenotypic changes and STAT5 signaling: 1,25-Dihydroxyvitamin D3 modulates the suppressor activity", 
  "url": "https://aperta.ulakbim.gov.tr/record/79097"
}