1 Ocak 2015 Dergi makalesi Açık Erişim

Alahgholi-Hajibehzad, Mandi; Oflazer, Piraye; Aysal, Fikret; Durmus, Hacer; Gulsen-Parman, Yesim; Marx, Alexander; Deymeer, Feza; Saruhan-Direskeneli, Guher

Citation Style Language JSON

{
  "DOI": "10.1016/j.jneuroim.2015.03.008", 
  "abstract": "Regulatory T cells were investigated in early-onset (EO) and late-onset (LO) myasthenia gravis patients with anti-acetylcholine receptor antibody (AChR-MG). Alterations in PD-1 and PD-L1 on CD4(+)CD25(++) (Treg) and responder T cells (Tresp, CD4(+)CD25(-)) were observed in LOMG patients. GITR was decreased on CD4(+)CD25(++) of all patients. Decrease of FOXP3 was associated with lower phosphorylation of STAT5.1,25-dihydroxyvitamin D3 (VitD3) increased suppression in co-culture with a stronger effect in patients by acting possibly both on cell groups. Changes in surface molecules and intracellular pathways contribute to the defects of Treg in non-thymomatous AChR-MG and VitD3 can have modulatory effects. (C) 2015 Elsevier B.V. All rights reserved.", 
  "author": [
    {
      "family": "Alahgholi-Hajibehzad", 
      "given": " Mandi"
    }, 
    {
      "family": "Oflazer", 
      "given": " Piraye"
    }, 
    {
      "family": "Aysal", 
      "given": " Fikret"
    }, 
    {
      "family": "Durmus", 
      "given": " Hacer"
    }, 
    {
      "family": "Gulsen-Parman", 
      "given": " Yesim"
    }, 
    {
      "family": "Marx", 
      "given": " Alexander"
    }, 
    {
      "family": "Deymeer", 
      "given": " Feza"
    }, 
    {
      "family": "Saruhan-Direskeneli", 
      "given": " Guher"
    }
  ], 
  "container_title": "JOURNAL OF NEUROIMMUNOLOGY", 
  "id": "79097", 
  "issued": {
    "date-parts": [
      [
        2015, 
        1, 
        1
      ]
    ]
  }, 
  "page": "51-60", 
  "title": "Regulatory function of CD4(+)CD25(++) T cells in patients with myasthenia gravis is associated with phenotypic changes and STAT5 signaling: 1,25-Dihydroxyvitamin D3 modulates the suppressor activity", 
  "type": "article-journal", 
  "volume": "281"
}