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Alahgholi-Hajibehzad, Mandi; Oflazer, Piraye; Aysal, Fikret; Durmus, Hacer; Gulsen-Parman, Yesim; Marx, Alexander; Deymeer, Feza; Saruhan-Direskeneli, Guher
{ "DOI": "10.1016/j.jneuroim.2015.03.008", "abstract": "Regulatory T cells were investigated in early-onset (EO) and late-onset (LO) myasthenia gravis patients with anti-acetylcholine receptor antibody (AChR-MG). Alterations in PD-1 and PD-L1 on CD4(+)CD25(++) (Treg) and responder T cells (Tresp, CD4(+)CD25(-)) were observed in LOMG patients. GITR was decreased on CD4(+)CD25(++) of all patients. Decrease of FOXP3 was associated with lower phosphorylation of STAT5.1,25-dihydroxyvitamin D3 (VitD3) increased suppression in co-culture with a stronger effect in patients by acting possibly both on cell groups. Changes in surface molecules and intracellular pathways contribute to the defects of Treg in non-thymomatous AChR-MG and VitD3 can have modulatory effects. (C) 2015 Elsevier B.V. All rights reserved.", "author": [ { "family": "Alahgholi-Hajibehzad", "given": " Mandi" }, { "family": "Oflazer", "given": " Piraye" }, { "family": "Aysal", "given": " Fikret" }, { "family": "Durmus", "given": " Hacer" }, { "family": "Gulsen-Parman", "given": " Yesim" }, { "family": "Marx", "given": " Alexander" }, { "family": "Deymeer", "given": " Feza" }, { "family": "Saruhan-Direskeneli", "given": " Guher" } ], "container_title": "JOURNAL OF NEUROIMMUNOLOGY", "id": "79097", "issued": { "date-parts": [ [ 2015, 1, 1 ] ] }, "page": "51-60", "title": "Regulatory function of CD4(+)CD25(++) T cells in patients with myasthenia gravis is associated with phenotypic changes and STAT5 signaling: 1,25-Dihydroxyvitamin D3 modulates the suppressor activity", "type": "article-journal", "volume": "281" }
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