1 Ocak 2015 Dergi makalesi Açık Erişim

Alahgholi-Hajibehzad, Mandi; Oflazer, Piraye; Aysal, Fikret; Durmus, Hacer; Gulsen-Parman, Yesim; Marx, Alexander; Deymeer, Feza; Saruhan-Direskeneli, Guher

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/79097</identifier>
  <creators>
    <creator>
      <creatorName>Alahgholi-Hajibehzad, Mandi</creatorName>
      <givenName>Mandi</givenName>
      <familyName>Alahgholi-Hajibehzad</familyName>
    </creator>
    <creator>
      <creatorName>Oflazer, Piraye</creatorName>
      <givenName>Piraye</givenName>
      <familyName>Oflazer</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aysal, Fikret</creatorName>
      <givenName>Fikret</givenName>
      <familyName>Aysal</familyName>
      <affiliation>Bakirkoy Res &amp; Training Hosp Psychiat &amp; Neurol Di, Dept Neurol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Durmus, Hacer</creatorName>
      <givenName>Hacer</givenName>
      <familyName>Durmus</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gulsen-Parman, Yesim</creatorName>
      <givenName>Yesim</givenName>
      <familyName>Gulsen-Parman</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Marx, Alexander</creatorName>
      <givenName>Alexander</givenName>
      <familyName>Marx</familyName>
      <affiliation>Heidelberg Univ, Univ Med Ctr Mannheim, Inst Pathol, Mannheim, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Deymeer, Feza</creatorName>
      <givenName>Feza</givenName>
      <familyName>Deymeer</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Saruhan-Direskeneli, Guher</creatorName>
      <givenName>Guher</givenName>
      <familyName>Saruhan-Direskeneli</familyName>
      <affiliation>Istanbul Univ, Dept Physiol, Istanbul Med Fac, Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Regulatory Function Of Cd4(+)Cd25(++) T Cells In Patients With Myasthenia Gravis Is Associated With Phenotypic Changes And Stat5 Signaling: 1,25-Dihydroxyvitamin D3 Modulates The Suppressor Activity</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2015</publicationYear>
  <dates>
    <date dateType="Issued">2015-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/79097</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.jneuroim.2015.03.008</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Regulatory T cells were investigated in early-onset (EO) and late-onset (LO) myasthenia gravis patients with anti-acetylcholine receptor antibody (AChR-MG). Alterations in PD-1 and PD-L1 on CD4(+)CD25(++) (Treg) and responder T cells (Tresp, CD4(+)CD25(-)) were observed in LOMG patients. GITR was decreased on CD4(+)CD25(++) of all patients. Decrease of FOXP3 was associated with lower phosphorylation of STAT5.1,25-dihydroxyvitamin D3 (VitD3) increased suppression in co-culture with a stronger effect in patients by acting possibly both on cell groups. Changes in surface molecules and intracellular pathways contribute to the defects of Treg in non-thymomatous AChR-MG and VitD3 can have modulatory effects. (C) 2015 Elsevier B.V. All rights reserved.</description>
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