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Alahgholi-Hajibehzad, Mandi; Oflazer, Piraye; Aysal, Fikret; Durmus, Hacer; Gulsen-Parman, Yesim; Marx, Alexander; Deymeer, Feza; Saruhan-Direskeneli, Guher
<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd"> <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/79097</identifier> <creators> <creator> <creatorName>Alahgholi-Hajibehzad, Mandi</creatorName> <givenName>Mandi</givenName> <familyName>Alahgholi-Hajibehzad</familyName> </creator> <creator> <creatorName>Oflazer, Piraye</creatorName> <givenName>Piraye</givenName> <familyName>Oflazer</familyName> <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey</affiliation> </creator> <creator> <creatorName>Aysal, Fikret</creatorName> <givenName>Fikret</givenName> <familyName>Aysal</familyName> <affiliation>Bakirkoy Res & Training Hosp Psychiat & Neurol Di, Dept Neurol, Istanbul, Turkey</affiliation> </creator> <creator> <creatorName>Durmus, Hacer</creatorName> <givenName>Hacer</givenName> <familyName>Durmus</familyName> <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey</affiliation> </creator> <creator> <creatorName>Gulsen-Parman, Yesim</creatorName> <givenName>Yesim</givenName> <familyName>Gulsen-Parman</familyName> <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey</affiliation> </creator> <creator> <creatorName>Marx, Alexander</creatorName> <givenName>Alexander</givenName> <familyName>Marx</familyName> <affiliation>Heidelberg Univ, Univ Med Ctr Mannheim, Inst Pathol, Mannheim, Germany</affiliation> </creator> <creator> <creatorName>Deymeer, Feza</creatorName> <givenName>Feza</givenName> <familyName>Deymeer</familyName> <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey</affiliation> </creator> <creator> <creatorName>Saruhan-Direskeneli, Guher</creatorName> <givenName>Guher</givenName> <familyName>Saruhan-Direskeneli</familyName> <affiliation>Istanbul Univ, Dept Physiol, Istanbul Med Fac, Istanbul, Turkey</affiliation> </creator> </creators> <titles> <title>Regulatory Function Of Cd4(+)Cd25(++) T Cells In Patients With Myasthenia Gravis Is Associated With Phenotypic Changes And Stat5 Signaling: 1,25-Dihydroxyvitamin D3 Modulates The Suppressor Activity</title> </titles> <publisher>Aperta</publisher> <publicationYear>2015</publicationYear> <dates> <date dateType="Issued">2015-01-01</date> </dates> <resourceType resourceTypeGeneral="Text">Journal article</resourceType> <alternateIdentifiers> <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/79097</alternateIdentifier> </alternateIdentifiers> <relatedIdentifiers> <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.jneuroim.2015.03.008</relatedIdentifier> </relatedIdentifiers> <rightsList> <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights> <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights> </rightsList> <descriptions> <description descriptionType="Abstract">Regulatory T cells were investigated in early-onset (EO) and late-onset (LO) myasthenia gravis patients with anti-acetylcholine receptor antibody (AChR-MG). Alterations in PD-1 and PD-L1 on CD4(+)CD25(++) (Treg) and responder T cells (Tresp, CD4(+)CD25(-)) were observed in LOMG patients. GITR was decreased on CD4(+)CD25(++) of all patients. Decrease of FOXP3 was associated with lower phosphorylation of STAT5.1,25-dihydroxyvitamin D3 (VitD3) increased suppression in co-culture with a stronger effect in patients by acting possibly both on cell groups. Changes in surface molecules and intracellular pathways contribute to the defects of Treg in non-thymomatous AChR-MG and VitD3 can have modulatory effects. (C) 2015 Elsevier B.V. All rights reserved.</description> </descriptions> </resource>
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