1 Ocak 2015 Dergi makalesi Açık Erişim

Alahgholi-Hajibehzad, Mandi; Oflazer, Piraye; Aysal, Fikret; Durmus, Hacer; Gulsen-Parman, Yesim; Marx, Alexander; Deymeer, Feza; Saruhan-Direskeneli, Guher

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        "name": "Alahgholi-Hajibehzad, Mandi"
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        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
        "name": "Oflazer, Piraye"
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      {
        "affiliation": "Bakirkoy Res & Training Hosp Psychiat & Neurol Di, Dept Neurol, Istanbul, Turkey", 
        "name": "Aysal, Fikret"
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      {
        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
        "name": "Durmus, Hacer"
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      {
        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
        "name": "Gulsen-Parman, Yesim"
      }, 
      {
        "affiliation": "Heidelberg Univ, Univ Med Ctr Mannheim, Inst Pathol, Mannheim, Germany", 
        "name": "Marx, Alexander"
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      {
        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
        "name": "Deymeer, Feza"
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        "affiliation": "Istanbul Univ, Dept Physiol, Istanbul Med Fac, Istanbul, Turkey", 
        "name": "Saruhan-Direskeneli, Guher"
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    "description": "Regulatory T cells were investigated in early-onset (EO) and late-onset (LO) myasthenia gravis patients with anti-acetylcholine receptor antibody (AChR-MG). Alterations in PD-1 and PD-L1 on CD4(+)CD25(++) (Treg) and responder T cells (Tresp, CD4(+)CD25(-)) were observed in LOMG patients. GITR was decreased on CD4(+)CD25(++) of all patients. Decrease of FOXP3 was associated with lower phosphorylation of STAT5.1,25-dihydroxyvitamin D3 (VitD3) increased suppression in co-culture with a stronger effect in patients by acting possibly both on cell groups. Changes in surface molecules and intracellular pathways contribute to the defects of Treg in non-thymomatous AChR-MG and VitD3 can have modulatory effects. (C) 2015 Elsevier B.V. All rights reserved.", 
    "doi": "10.1016/j.jneuroim.2015.03.008", 
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    "journal": {
      "pages": "51-60", 
      "title": "JOURNAL OF NEUROIMMUNOLOGY", 
      "volume": "281"
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    "publication_date": "2015-01-01", 
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    "title": "Regulatory function of CD4(+)CD25(++) T cells in patients with myasthenia gravis is associated with phenotypic changes and STAT5 signaling: 1,25-Dihydroxyvitamin D3 modulates the suppressor activity"
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