1 Ocak 2019 Dergi makalesi Açık Erişim

Onat, Bora; Ulusan, Sinem; Banerjee, Sreeparna; Erel-Goktepe, Irem

Dublin Core

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  <dc:creator>Onat, Bora</dc:creator>
  <dc:creator>Ulusan, Sinem</dc:creator>
  <dc:creator>Banerjee, Sreeparna</dc:creator>
  <dc:creator>Erel-Goktepe, Irem</dc:creator>
  <dc:date>2019-01-01</dc:date>
  <dc:description>We report the surface modification of chitosan/poly(ethylene glycol) (chitosan/PEG) hydrogel materials via layer-by-layer (LbL) technique using stimuli-responsive polymers. Water-soluble complexes of Tannic Acid (TA) and a broad-spectrum antibiotic, Ciprofloxacin (Cipro) were prepared and co-assembled at the surface of Chitosan/PEG hydrogels with poly(N-vinyl caprolactam) (PVCL). Compared to the bare hydrogels, the surface spreading and proliferation of human fibroblasts were significantly enhanced on precast hydrogels coated with TA-Cipro/PVCL multilayers. LbL coating also provided enhanced Cipro release from the hydrogel surface at 37 degrees C compared to bare hydrogels. TA-Cipro/PVCL coated hydrogels showed antibacterial activity through chitosan and temperature-induced release of Cipro from multilayers. Chitosan and Cipro showed a coordinated antibacterial effect on Eschericia coli and Bacillus cereus, reducing their minimum inhibitory concentration (MIC). This effect was more pronounced on B. cereus. LbL modification of chitosan-based hydrogels using stimuli responsive polymers can be advantageous for bringing multiple functionalities to these materials without sacrificing their intrinsic properties such as antibacterial activity and biocompatibility. Such LbL-coated hydrogels hold promise in wound treatment as they may promote fibroblast proliferation and skin tissue regeneration.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/74303</dc:identifier>
  <dc:identifier>oai:zenodo.org:74303</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>EUROPEAN POLYMER JOURNAL 112 73-86</dc:source>
  <dc:title>Multifunctional layer-by-layer modified chitosan/poly(ethylene glycol) hydrogels</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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