1 Ocak 2019 Dergi makalesi Açık Erişim

Onat, Bora; Ulusan, Sinem; Banerjee, Sreeparna; Erel-Goktepe, Irem

Citation Style Language JSON

{
  "DOI": "10.1016/j.eurpolymj.2018.12.028", 
  "abstract": "We report the surface modification of chitosan/poly(ethylene glycol) (chitosan/PEG) hydrogel materials via layer-by-layer (LbL) technique using stimuli-responsive polymers. Water-soluble complexes of Tannic Acid (TA) and a broad-spectrum antibiotic, Ciprofloxacin (Cipro) were prepared and co-assembled at the surface of Chitosan/PEG hydrogels with poly(N-vinyl caprolactam) (PVCL). Compared to the bare hydrogels, the surface spreading and proliferation of human fibroblasts were significantly enhanced on precast hydrogels coated with TA-Cipro/PVCL multilayers. LbL coating also provided enhanced Cipro release from the hydrogel surface at 37 degrees C compared to bare hydrogels. TA-Cipro/PVCL coated hydrogels showed antibacterial activity through chitosan and temperature-induced release of Cipro from multilayers. Chitosan and Cipro showed a coordinated antibacterial effect on Eschericia coli and Bacillus cereus, reducing their minimum inhibitory concentration (MIC). This effect was more pronounced on B. cereus. LbL modification of chitosan-based hydrogels using stimuli responsive polymers can be advantageous for bringing multiple functionalities to these materials without sacrificing their intrinsic properties such as antibacterial activity and biocompatibility. Such LbL-coated hydrogels hold promise in wound treatment as they may promote fibroblast proliferation and skin tissue regeneration.", 
  "author": [
    {
      "family": "Onat", 
      "given": " Bora"
    }, 
    {
      "family": "Ulusan", 
      "given": " Sinem"
    }, 
    {
      "family": "Banerjee", 
      "given": " Sreeparna"
    }, 
    {
      "family": "Erel-Goktepe", 
      "given": " Irem"
    }
  ], 
  "container_title": "EUROPEAN POLYMER JOURNAL", 
  "id": "74303", 
  "issued": {
    "date-parts": [
      [
        2019, 
        1, 
        1
      ]
    ]
  }, 
  "page": "73-86", 
  "title": "Multifunctional layer-by-layer modified chitosan/poly(ethylene glycol) hydrogels", 
  "type": "article-journal", 
  "volume": "112"
}