1 Ocak 2019 Dergi makalesi Açık Erişim

Onat, Bora; Ulusan, Sinem; Banerjee, Sreeparna; Erel-Goktepe, Irem

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/74303</identifier>
  <creators>
    <creator>
      <creatorName>Onat, Bora</creatorName>
      <givenName>Bora</givenName>
      <familyName>Onat</familyName>
      <affiliation>Middle East Tech Univ, Dept Biotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ulusan, Sinem</creatorName>
      <givenName>Sinem</givenName>
      <familyName>Ulusan</familyName>
      <affiliation>Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Banerjee, Sreeparna</creatorName>
      <givenName>Sreeparna</givenName>
      <familyName>Banerjee</familyName>
      <affiliation>Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Erel-Goktepe, Irem</creatorName>
      <givenName>Irem</givenName>
      <familyName>Erel-Goktepe</familyName>
    </creator>
  </creators>
  <titles>
    <title>Multifunctional Layer-By-Layer Modified Chitosan/Poly(Ethylene Glycol) Hydrogels</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/74303</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.eurpolymj.2018.12.028</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">We report the surface modification of chitosan/poly(ethylene glycol) (chitosan/PEG) hydrogel materials via layer-by-layer (LbL) technique using stimuli-responsive polymers. Water-soluble complexes of Tannic Acid (TA) and a broad-spectrum antibiotic, Ciprofloxacin (Cipro) were prepared and co-assembled at the surface of Chitosan/PEG hydrogels with poly(N-vinyl caprolactam) (PVCL). Compared to the bare hydrogels, the surface spreading and proliferation of human fibroblasts were significantly enhanced on precast hydrogels coated with TA-Cipro/PVCL multilayers. LbL coating also provided enhanced Cipro release from the hydrogel surface at 37 degrees C compared to bare hydrogels. TA-Cipro/PVCL coated hydrogels showed antibacterial activity through chitosan and temperature-induced release of Cipro from multilayers. Chitosan and Cipro showed a coordinated antibacterial effect on Eschericia coli and Bacillus cereus, reducing their minimum inhibitory concentration (MIC). This effect was more pronounced on B. cereus. LbL modification of chitosan-based hydrogels using stimuli responsive polymers can be advantageous for bringing multiple functionalities to these materials without sacrificing their intrinsic properties such as antibacterial activity and biocompatibility. Such LbL-coated hydrogels hold promise in wound treatment as they may promote fibroblast proliferation and skin tissue regeneration.</description>
  </descriptions>
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